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洛索洛芬

洛索洛芬用途

Loxoprofen是非甾体抗炎化合物。

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洛索洛芬名称

[ CAS 号 ]:
68767-14-6

[ 中文名 ]:
洛索洛芬

[ 英文名 ]:
Loxoprofen

[中文别名 ]:

[英文别名 ]:

IOXOPROFEN
MFCD00864331
KOLOXO
Loxoprofen

洛索洛芬生物活性

[ 描述 ]:

Loxoprofen是非甾体抗炎化合物。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX-1:6.5 μM (IC50, in human whole blood)

COX-2:13.5 μM (IC50, in human whole blood)

[参考文献]

[1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3.

[相关活性小分子]

洛索洛芬物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
417.9±20.0 °C at 760 mmHg

[ 熔点 ]:
108.5 - 111ºC

[ 分子式 ]:
C₁₅H₁₈O₃

[ 分子量 ]:
246.302

[ 闪点 ]:
220.7±18.3 °C

[ 精确质量 ]:
246.125595

[ PSA ]:
54.37000

[ LogP ]:
1.87

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
室温

[ 水溶解性 ]:
可溶于：甲醇

洛索洛芬MSDS

洛索洛芬安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918300090

洛索洛芬合成路线

洛索洛芬上下游产品

洛索洛芬上游产品

洛索洛芬下游产品

洛索洛芬制备

2-氧环戊烷羧酸乙酯和氢氧化钾在二甲基甲酰胺中，在80℃和2-(4-氯-基苯基)丙酸乙酯反应2h。得到的产物和47%氢溴酸反应，水解脱羧，得洛索洛芬。

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洛索洛芬海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

洛索洛芬文献

Determination of nonsteroidal anti-inflammatory drugs in human tear and plasma samples using ultra-fast liquid chromatography-tandem mass spectrometry.

Jpn. J. Ophthalmol. 59 , 364-71, (2015)

To evaluate a new rapid and sensitive method for analyzing human tears and plasma for nonsteroidal anti-inflammatory drugs (NSAIDs) and investigate the influence of the transfer of NSAIDs in an ocular...

Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study.

J. Gastroenterol. Hepatol. 30(2) , 292-8, (2015)

The associations between antithrombotic or antihypertensive drugs and peptic ulcer bleeding (PUB) remain unknown, particularly in Asia, where Helicobacter pylori infection is prevalent. This study aim...

Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment.

Drug Dev. Ind. Pharm. 41 , 953-8, (2015)

X-ray inspection equipment is widely used to detect missing materials and defective goods in opaque containers. Its application has been expanded to the pharmaceutical industry to detect the presence ...

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