氯化筒箭毒碱五水合物

氯化筒箭毒碱五水合物用途

D-Tubocurarine chloride pentahydrate 是微管尿素的氯化物盐形式,是烟碱乙酰胆碱受体 (AChR) 的拮抗剂,可在手术或机械通气期间用作骨骼肌松弛剂。D-Tubocurarine chloride pentahydrate 也是一种有效的神经肌肉阻滞剂。

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氯化筒箭毒碱五水合物名称

[ CAS 号 ]:
6989-98-6

[ 中文名 ]:
氯化南美防己碱

[ 英文名 ]:
(+)-TUBOCURARINE CHLORIDE PENTAHYDRATE

[中文别名 ]:

[英文别名 ]:

MFCD00150157
(+)-tubocurarine chloride pentahydrate

氯化筒箭毒碱五水合物生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[体外研究]

AChR拮抗剂tubocucurarine(10μM)对Caco-2细胞的作用导致粘附连接的破坏。水牛乳源性产品(MBCP)(18μM)减弱了Tubocurarine-AChR拮抗剂对Caco-2细胞粘附连接的作用[1]。

[参考文献]

[1]. Tenore GC, et al. Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese. Nutrients. 2019 Mar 13;11(3). pii: E610.

[2]. Min CH, et al. The comparative effects of aminoglycoside antibiotics and muscle relaxants on electrical field stimulation response in rat bladder smooth muscle. Arch Pharm Res. 2016 Jun;39(6):863-70.

[3]. P. W. Codding, et al. The crystal and molecular structure of a potent neuromuscular blocking agent: d-tubocurarine dichloride pentahydrate. Acta Cryst. (1973). B29, 935.

氯化筒箭毒碱五水合物物理化学性质

[ 密度 ]:
1.2074 (rough estimate)

[ 熔点 ]:
275-280ºC (dec.)(lit.)

[ 分子式 ]:
C₃₇H₅₂Cl₂N₂O₁₁

[ 分子量 ]:
771.72200

[ 精确质量 ]:
770.29500

[ PSA ]:
126.77000

[ LogP ]:
4.08220

[ 折射率 ]:
193 ° (C=1, H2O)

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow | Soluble in water to 50mg/ml, with warming as needed. Also soluble in ethanol or methanol

氯化筒箭毒碱五水合物MSDS

详细MSDS(安全技术说明书)

氯化筒箭毒碱五水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YO5100000

CHEMICAL NAME :: Tubocurarine, dichloride, pentahydrate, (+)-

CAS REGISTRY NUMBER :: 6989-98-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C37-H41-N2-O6.Cl-H.Cl.5H2-O

MOLECULAR WEIGHT :: 771.81

WISWESSER LINE NOTATION :: T D6 I6 I-6 R6-18-66 D- D-- I-- R- 2AI- H& CO JK QO B&K&T&&TT&J J1 J1 OO1 SQ B&1 B&1 G&O1 H&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 150 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,109,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 270 ug/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 97,19,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,395,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 421 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,558,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,333,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,388,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,395,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 400 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,395,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 146 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,395,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 5280 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,558,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 840 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,558,1960

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氯化筒箭毒碱五水合物安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S22;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 1544 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
YO5100000

[ 包装等级 ]:
III

氯化筒箭毒碱五水合物文献

Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation.

Am. J. Physiol. Cell Physiol. 296 , C1195-206, (2009)

Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentia...

Interaction of d-tubocurarine analogs with the mouse nicotinic acetylcholine receptor. Ligand orientation at the binding site.

J. Biol. Chem. 272 , 24891-24898, (1997)

The binding of d-tubocurarine and several of its analogs to the mouse nicotinic acetylcholine receptor (AChR) was measured by competition against the initial rate 125I-alpha-bungarotoxin binding to BC...

Acetylcholine receptor inhibition by d-tubocurarine involves both a competitive and a noncompetitive binding site as determined by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles.

Biochemistry 25 , 1786, (1986)

The issue of whether d-tubocurarine, the classical acetylcholine receptor inhibitor, inhibits the receptor by a competitive or noncompetitive mechanism has long been controversial. d-Tubocurarine, in ...

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