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3-碘-L-酪氨酸

3-碘-L-酪氨酸用途

H-Tyr(3-I)-OH 是一种有效的酪氨酸羟化酶抑制剂。

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3-碘-L-酪氨酸名称

[ CAS 号 ]:
70-78-0

[ 中文名 ]:
3-碘-L-酪氨酸

[ 英文名 ]:
3-Iodo-L-tyrosine

[中文别名 ]:

3-碘-L-苯酚氨基丙酸

[英文别名 ]:

3-Iodotyrosine
EINECS 200-744-8
3-IODO-L-TYROSINE
MFCD00002608
Monoiodotyrosine
3-Monoiodo-L-tyrosine
Tyrosine, 3-iodo-, L-
Tyrosine, 3-iodo-
H-Tyr(3-I)-OH

3-碘-L-酪氨酸生物活性

[ 描述 ]:

H-Tyr(3-I)-OH 是一种有效的酪氨酸羟化酶抑制剂。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

H-Tyr(3-I)-OH(3-碘-L-酪氨酸)是酪氨酸羟化酶的有效抑制剂。浓度为100μM时,3-碘-L-酪氨酸抑制酶活性100％,浓度为10μM时抑制60-70％[1]。

[参考文献]

[1]. GOLDSTEIN M, et al. INHIBITION OF TYROSINE HYDROXYLASE BY 3-IODO-L-TYROSINE. Life Sci (1962). 1965 Jan;4:261-4.

[相关活性小分子]

3-碘-L-酪氨酸物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
391.0±42.0 °C at 760 mmHg

[ 熔点 ]:
210 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₀INO₃

[ 分子量 ]:
307.085

[ 闪点 ]:
190.3±27.9 °C

[ 精确质量 ]:
306.970520

[ PSA ]:
83.55000

[ LogP ]:
1.54

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.689

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
dilute aqueous acid: soluble

3-碘-L-酪氨酸MSDS

详细MSDS(安全技术说明书)

3-碘-L-酪氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

3-碘-L-酪氨酸上下游产品

3-碘-L-酪氨酸上游产品

3-碘-L-酪氨酸下游产品

3-碘-L-酪氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-碘-L-酪氨酸文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium.

Pharm. Dev. Technol. 20(3) , 314-9, (2015)

Levothyroxine sodium is an important medication used primarily for treating patients with hypothyroidism. Levothyroxine sodium tablets have been recalled many times since their 1955 introduction to th...

Protein stabilization utilizing a redefined codon.

Sci. Rep. 5 , 9762, (2015)

Recent advances have fundamentally changed the ways in which synthetic amino acids are incorporated into proteins, enabling their efficient and multiple-site incorporation, in addition to the 20 canon...

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