N-(2-氨基丙酰基)-2,6-二甲基苯胺

N-(2-氨基丙酰基)-2,6-二甲基苯胺用途

Tocainide hydrochloride 是一种 sodium channel 阻滞剂,在产生疼痛的病灶中(神经膜上) 阻断钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物,用于治疗心律不齐。

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N-(2-氨基丙酰基)-2,6-二甲基苯胺名称

[ CAS 号 ]:
71395-14-7

[ 中文名 ]:
N-(2-氨基丙酰基)-2,6-二甲基苯胺

[ 英文名 ]:
Tocainide hydrochloride

[英文别名 ]:

Tobramycin sulfate [usan]
Tocainidhydrochlorid
6'-propionoxylidide hydrochloride
TOBRAMYCIN SULPHATE

N-(2-氨基丙酰基)-2,6-二甲基苯胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: sodium channel[1]

[体内研究]

托卡宁(100mg/kg)能有效抑制冠状动脉闭塞犬的室性异位活动。在洋地黄毒性和冠状动脉闭塞模型终止妥卡胺输注导致心室异位活动的迅速返回[1 ]。

[参考文献]

[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23.

[2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45.

N-(2-氨基丙酰基)-2,6-二甲基苯胺物理化学性质

[ 分子式 ]:
C₁₁H₁₇ClN₂O

[ 分子量 ]:
192.25800

[ 精确质量 ]:
192.12600

[ PSA ]:
55.12000

[ LogP ]:
2.36240

[ 储存条件 ]:
2-8°C，密封，干燥，惰性气体

N-(2-氨基丙酰基)-2,6-二甲基苯胺MSDS

详细MSDS(安全技术说明书)

N-(2-氨基丙酰基)-2,6-二甲基苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

N-(2-氨基丙酰基)-2,6-二甲基苯胺文献

Synthesis, structure and pharmacology of acyl-2,6-xylidines.

Acta Pol. Pharm. 61(3) , 215-21, (2004)

L-2-perhydroheterocyclicalkyl acids were condensed with 2,6-xylidine. 8 new optically active acyl-2,6-xylidines were obtained. Absolute configuration of acyl-2,6-xylidines were selected for pharmacolo...

Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.

J. Mol. Graph. Model. 24(5) , 383-95, (2006)

Quantitative structure-pharmacokinetic relationships (QSPkR) have increasingly been used for the prediction of the pharmacokinetic properties of drug leads. Several QSPkR models have been developed to...

The efficacy of anticonvulsants on orofacial pain: a systematic review.

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 111(5) , 627-33, (2011)

Controversy exists about the effectiveness of anticonvulsants for the management of orofacial pain disorders. To ascertain appropriate therapies, a systematic review was conducted of existing randomiz...

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