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(±)-盐酸喹吡罗

(±)-盐酸喹吡罗用途

rel-Quinpirole (rel-LY 141865) dihydrochloride 是一种麦角化合物,是一种选择性多巴胺 D2 受体激动剂。rel-Quinpirole dihydrochloride 可用于神经系统疾病的研究。

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(±)-盐酸喹吡罗名称

[ CAS 号 ]:
73625-62-4

[ 中文名 ]:
(±)-盐酸喹吡罗

[ 英文名 ]:
Quinpirole dihydrochloride

[英文别名 ]:

(+/-)-quinpirole dihydrochloride

(±)-盐酸喹吡罗生物活性

[ 描述 ]:

rel-Quinpirole (rel-LY 141865) dihydrochloride 是一种麦角化合物,是一种选择性多巴胺 D2 受体激动剂。rel-Quinpirole dihydrochloride 可用于神经系统疾病的研究。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. X T Hu, et al. Disinhibition of nucleus accumbens neurons by the dopamine D2 receptor agonist LY-141865: prevented by 6-OHDA pretreatment. Brain Res. 1988 Mar 22;444(2):389-93.

(±)-盐酸喹吡罗物理化学性质

[ 分子式 ]:
C₁₃H₂₂ClN₃

[ 分子量 ]:
255.78700

[ 精确质量 ]:
255.15000

[ PSA ]:
31.92000

[ LogP ]:
2.73880

(±)-盐酸喹吡罗安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(±)-盐酸喹吡罗文献

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

J. Neurosci. 31 , 5512-25, (2011)

An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,...

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.

Hum. Mol. Genet. 24(7) , 1929-44, (2015)

The essential micronutrient manganese is enriched in brain, especially in the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, a...

Biphasic effect of D-2 agonist quinpirole on locomotion and movements.

Eur. J. Pharmacol. 161 , 151-157, (1989)

The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the d...

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