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腺苷5′-三磷酸镁盐

腺苷5′-三磷酸镁盐用途

ATP(腺苷5'-三磷酸)二镁是体内能量储存和代谢的中心成分。ATP二镁提供代谢能量以驱动代谢泵,并在细胞中充当辅酶。ATP二镁是免疫和炎症中重要的内源性信号分子[1][2]。

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腺苷5′-三磷酸镁盐名称

[ CAS 号 ]:
74804-12-9

[ 中文名 ]:
腺甘三磷酸

[ 英文名 ]:
Adenosine 5'-triphosphate magnesium salt

[中文别名 ]:

ATP 镁盐

[英文别名 ]:

Adenosine 5'-triphosphate magnesium salt
ATP magnesium salt
ATP-MG

腺苷5′-三磷酸镁盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

ATP(5mM；1小时)与LPS(1μ。ATP(2mM；0.5-24小时)以caspase-1激活依赖性方式诱导BMDMs分泌IL-1β、KC和MIP-2[4]。ATP在体外促进中性粒细胞趋化[4]。

[体内研究]

ATP(50 mg/kg；i.p.)在体内保护小鼠免受细菌感染[4]。ATP诱导体内IL-1β、KC和MIP-2的分泌以及中性粒细胞的募集[4]。动物模型：4周龄昆明小鼠(18-22g)[4]剂量：50mg/kg给药：在细菌(大肠杆菌)攻击前腹腔注射。结果：保护小鼠免受细菌感染。

[参考文献]

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

[2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.

[3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.

[4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.

腺苷5′-三磷酸镁盐物理化学性质

[ 分子式 ]:
C₁₀H₁₄MgN₅O₁₃P₃

[ 分子量 ]:
529.47000

[ 精确质量 ]:
528.96500

[ PSA ]:
314.22000

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

腺苷5′-三磷酸镁盐MSDS

详细MSDS(安全技术说明书)

腺苷5′-三磷酸镁盐安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H371

[ 警示性声明 ]:
P260

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-68/20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

腺苷5′-三磷酸镁盐文献

Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function.

Behav. Brain Res. 270 , 151-8, (2014)

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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.

Malaria Journal 13 , 359, (2014)

Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolis...

Mitochondrial recoupling: a novel therapeutic strategy for cancer?

Br. J. Cancer 105 , 469-474, (2011)

Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of...

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