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2-氨基-1-苯基乙醇

2-氨基-1-苯基乙醇用途

2-Amino-1-phenylethanol 为去甲肾上腺素类似物。

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2-氨基-1-苯基乙醇名称

[ CAS 号 ]:
7568-93-6

[ 中文名 ]:
2-氨基-1-苯乙醇

[ 英文名 ]:
phenylethanolamine

[中文别名 ]:

[英文别名 ]:

Ethanol, 2- (phenylamino)-
β-Anilinoethanol
a-(Aminomethyl)benzyl alcohol
α-(Aminomethyl)benzyl alcohol
EINECS 231-469-1
N-(β-hydroxy)ethylaniline
phenylethanolamine
Aniline, N-(β-hydroxyethyl)-
b-Hydroxyphenethylamine
Ethanol, 2-(phenylamino)-

2-氨基-1-苯基乙醇生物活性

[ 描述 ]:

2-Amino-1-phenylethanol 为去甲肾上腺素类似物。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Melandri S, et al. Shape of biomolecules by free jet microwave spectroscopy: 2-amino-1-phenylethanol and 2-methylamino-1-phenylethanol. J Phys Chem A. 2009 Jul 9;113(27):7769-73.

[相关活性小分子]

2-氨基-1-苯基乙醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
286.9±13.0 °C at 760 mmHg

[ 熔点 ]:
56-58 °C(lit.)

[ 分子式 ]:
C₈H₁₁NO

[ 分子量 ]:
137.179

[ 闪点 ]:
151.4±10.5 °C

[ 精确质量 ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.82

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, acids, acid chlorides, acid anhydrides.

2-氨基-1-苯基乙醇MSDS

2-氨基-1-苯基乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN5500000

CHEMICAL NAME :: Benzyl alcohol, alpha-(aminomethyl)-

CAS REGISTRY NUMBER :: 7568-93-6

BEILSTEIN REFERENCE NO. :: 0971222

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: Z1YQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 686 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 153,161,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,73,1948 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

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2-氨基-1-苯基乙醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DN5500000

2-氨基-1-苯基乙醇合成路线

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2-氨基-1-苯基乙醇文献

A quantum dot based electrochemiluminescent immunosensor for the detection of pg level phenylethanolamine A using gold nanoparticles as substrates and electron transfer accelerators.

Analyst 139(17) , 4365-72, (2014)

This study reports the development of an electrochemiluminescent (ECL) immunosensor for ultrasensitive detection of phenylethanolamine A (PA) based on CdSe quantum dots (QDs) and gold nanoparticles (G...

Development and validation of a sensitive method for simultaneous determination of eight β₂-agonists in pork by ultrasonic-assisted extraction and liquid chromatography/tandem mass spectrometry.

J. Chromatogr. Sci. 53(1) , 104-11, (2014)

A simple and sensitive ultrasonic-assisted extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry was developed for the simultaneous determination of eight β2-agonists (i.e....

Simultaneous determination of plasma phenethylamine, phenylethanolamine, tyramine and octopamine by high-performance liquid chromatography using derivatization with fluorescamine.

J. Chromatogr. A. 427(2) , 320-5, (1988)

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