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4-溴钙离子载体

4-溴钙离子载体用途

4-Bromo A23187 是 A-23187 的卤代类似物。A-2318 是一种高选择性钙离子载体。4-Bromo A23187 是一种钙 (calcium) 调节剂,可诱导细胞凋亡 (apoptosis),比如 HL-60 细胞。

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4-溴钙离子载体名称

[ CAS 号 ]:
76455-48-6

[ 中文名 ]:
4-溴钙离子载体

[ 英文名 ]:
4-Bromo-antibiotic

4-溴钙离子载体生物活性

[ 描述 ]:

4-Bromo A23187 是 A-23187 的卤代类似物。A-2318 是一种高选择性钙离子载体。4-Bromo A23187 是一种钙 (calcium) 调节剂,可诱导细胞凋亡 (apoptosis),比如 HL-60 细胞。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Zhu WH, et al. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57(23):2091-9.

4-溴钙离子载体物理化学性质

[ 密度 ]:
1.43g/cm3

[ 沸点 ]:
735.4ºC at 760 mmHg

[ 分子式 ]:
C₂₉H₃₆BrN₃O₆

[ 分子量 ]:
602.51700

[ 闪点 ]:
398.5ºC

[ 精确质量 ]:
601.17900

[ PSA ]:
126.68000

[ LogP ]:
6.36530

[ 折射率 ]:
1.628

[ 储存条件 ]:
-20°C

4-溴钙离子载体安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

4-溴钙离子载体文献

Mast cell histamine-induced calcium transients in cultured human peritoneal mesothelial cells.

Perit. Dial. Int. 18(6) , 626-36, (1998)

Peritoneal inflammation results from a complex interplay of events initiated by macrophage activity in response to infection, with the stimulation of mesothelial cell cytokine release amplifying the r...

Activity-dependent development of calcium regulation in growing motor axons.

J. Neurosci. 18(13) , 4966-72, (1998)

In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2...

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.

J. Biol. Chem. 284(29) , 19744-53, (2009)

The Na/H exchanger 3 (NHE3) and the Cl/HCO(3) exchanger down-regulated in adenoma (DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca(2+)(i) inhibits NHE3 through mechanis...

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