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金刚烷胺

金刚烷胺用途

金刚烷胺(1-金刚烷胺)是一种具有抗甲型流感病毒活性的抗病毒药物。金刚烷胺阻止质子通过M2离子通道(甲型流感的M2质子通道),从而阻止病毒RNA释放到感染细胞的细胞质中。金刚烷胺是一种抗帕金森病药物[1][2]。

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金刚烷胺名称

[ CAS 号 ]:
768-94-5

[ 中文名 ]:
1-金刚烷胺

[ 英文名 ]:
Adamantan-1-amine

[中文别名 ]:

[英文别名 ]:

1-Adamantanamine
EXP 105-1
1-Amantadine
(3s,5s,7s)-adamantan-1-amine
adamantan-1-amine
tricyclo[3.3.1.13,7]decan-1-amine
Symmetrel
TCMDC-125869
Tricyclo[3.3.1.1]decan-1-amine
SYMADINE

金刚烷胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

[参考文献]

[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.

[2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

金刚烷胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
225.7±8.0 °C at 760 mmHg

[ 熔点 ]:
206-208 °C(lit.)

[ 分子式 ]:
C₁₀H₁₇N

[ 分子量 ]:
151.249

[ 闪点 ]:
96.0±9.7 °C

[ 精确质量 ]:
151.136093

[ PSA ]:
26.02000

[ LogP ]:
2.22

[ 外观性状 ]:
白色至淡黄色粉末/大块

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
可溶于：甲醇

金刚烷胺MSDS

详细MSDS(安全技术说明书)

金刚烷胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD1925000

CHEMICAL NAME :: Tricyclo(3.3.1.1(sup 3,7))decan-1-amine

CAS REGISTRY NUMBER :: 768-94-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H17-N

MOLECULAR WEIGHT :: 151.28

WISWESSER LINE NOTATION :: L66 B6 A B- C 1B ITJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

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金刚烷胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YD1925000

金刚烷胺上下游产品

金刚烷胺上游产品

金刚烷胺下游产品

金刚烷胺制备

由金刚烷溴化后再与尿素反应而得。工艺过程如下：将金刚烷加入干燥的搪玻璃反应罐中，滴加溴素，缓慢升温，在1h内从50℃升到65-75℃，回流反应6h，最终温度达到110℃（随着反应物的变化，物料沸点逐渐升高）。反应后放置过夜。然后升至45℃，滴加7%亚硫酸氢钠溶液以除去过剩的溴，过滤，滤饼用水洗至pH=7，自然干燥，得溴代金刚烷。将溴代金刚烷和尿素混合均匀，加热至180℃，反应开始，内温猛升到230-240℃。反应结束后，自然降温，加入浓盐酸溶解，移入蒸馏罐中，加入氢氧化钠碱化，然后进行水蒸汽蒸馏，得金刚烷胺。

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金刚烷胺文献

Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II.

Arch. Virol. 160(5) , 1163-70, (2015)

Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses...

CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes.

Colloids Surf. B Biointerfaces 105 , 31-6, (2013)

This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped...

A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.

Aquat. Toxicol. 159 , 127-37, (2015)

The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in v...

更多文献

金刚烷胺

金刚烷胺用途

金刚烷胺名称

金刚烷胺生物活性

金刚烷胺物理化学性质

金刚烷胺MSDS

详细MSDS(安全技术说明书)

金刚烷胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

金刚烷胺安全信息

金刚烷胺上下游产品

金刚烷胺上游产品

金刚烷胺下游产品

金刚烷胺制备

金刚烷胺文献

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