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氯苯沙明

氯苯沙明用途

Chlorphenoxamine是一种抗组胺剂和抗胆碱能药, 用作抗帕金森氏病。

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氯苯沙明名称

[ CAS 号 ]:
77-38-3

[ 中文名 ]:
氯苯沙明

[ 英文名 ]:
Chlorphenoxamine

[中文别名 ]:

[英文别名 ]:

Clorfenossamina [DCIT]
Chlorphenoxamine [INN:BAN]
Clorfenoxamina [INN-Spanish]
Chlorphenoxaminum [INN-Latin]
Contristamine
Chlorphenoxamine

氯苯沙明生物活性

[ 描述 ]:

Chlorphenoxamine是一种抗组胺剂和抗胆碱能药, 用作抗帕金森氏病。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 神经疾病

[相关活性小分子]

氯苯沙明物理化学性质

[ 密度 ]:
1.093g/cm3

[ 沸点 ]:
383.7ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₂ClNO

[ 分子量 ]:
303.82600

[ 闪点 ]:
185.9ºC

[ 精确质量 ]:
303.13900

[ PSA ]:
12.47000

[ LogP ]:
4.18170

[ 折射率 ]:
1.551

[ 储存条件 ]:
2-8°C

氯苯沙明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KR3185000

CHEMICAL NAME :: Ethylamine, 2-(1-(p-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-

CAS REGISTRY NUMBER :: 77-38-3

BEILSTEIN REFERENCE NO. :: 2057618

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-Cl-N-O

MOLECULAR WEIGHT :: 303.86

WISWESSER LINE NOTATION :: GR DX1&R&O2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 376 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 167 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957

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氯苯沙明安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2922199090

氯苯沙明合成路线

详细合成路线

氯苯沙明上下游产品

氯苯沙明上游产品

氯苯沙明下游产品

氯苯沙明海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%