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盐酸美克洛嗪

盐酸美克洛嗪用途

Meclizine是H1组胺受体拮抗剂,可作用于晕动病。

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盐酸美克洛嗪名称

[ CAS 号 ]:
1104-22-9

[ 中文名 ]:
盐酸美克洛嗪

[ 英文名 ]:
Meclizine dihydrochloride

[中文别名 ]:

盐酸氯苯苄嗪

[英文别名 ]:

EINECS 214-164-8
Meclizine diHCl
UNII:L997QXC9J1
ancolandihydrochloride
Meclizine (dihydrochloride)
Meclozine Hcl
UNII:408UZ554UD
diadril
Meclozine dihydrochloride
UNII:V5604WJ3XP

盐酸美克洛嗪生物活性

[ 描述 ]:

Meclizine是H1组胺受体拮抗剂,可作用于晕动病。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. King, C.T., S.A. Weaver, and S.A. Narrod, Antihistamines and Teratogenicity in the Rat. J Pharmacol Exp Ther, 1965. 147: p. 391-8.

[2]. Huang, W., et al., Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol, 2004. 18(10): p. 2402-8.

[相关活性小分子]

盐酸美克洛嗪物理化学性质

[ 密度 ]:
1.159g/cm3

[ 沸点 ]:
495.3ºC at 760mmHg

[ 熔点 ]:
212 °C

[ 分子式 ]:
C₂₅H₂₉Cl₃N₂

[ 分子量 ]:
463.870

[ 闪点 ]:
253.3ºC

[ 精确质量 ]:
462.139618

[ PSA ]:
6.48000

[ LogP ]:
7.03540

[ 外观性状 ]:
白色,略淡黄色,结晶粉末

[ 蒸汽压 ]:
6E-10mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：不溶；易溶于：氯仿；微溶：醇；不溶：乙醚

盐酸美克洛嗪MSDS

盐酸美克洛嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL2005000

CHEMICAL NAME :: Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 1104-22-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C25-H27-Cl-N2.2Cl-H

MOLECULAR WEIGHT :: 463.91

WISWESSER LINE NOTATION :: T6N DNTJ AYR&R DG& D1R C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,67,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory obstruction

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,653,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 800 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 800 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,375,1966

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盐酸美克洛嗪安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H361

[ 警示性声明 ]:
P280-P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TL2005000

[ 海关编码 ]:
2933499090

盐酸美克洛嗪合成路线

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盐酸美克洛嗪海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%