氯丙酮
氯丙酮用途
用于有机合成,制备药物、杀虫剂、香料和染料等
【用途二】
氯丙酮又名一氯丙酮,是一种有机合成原料,在农药上是三嗪酮类杀虫剂吡嗪酮的中间体,在其他方面可用于医药、染料、香料、抗氧剂、干燥剂、乙烯型感光树脂、彩色电影胶片偶联剂等的生产。
【用途三】
用作有机合成中间体,用于染料、杀虫剂、药物、香料、抗氧剂、干燥剂、乙烯型感光树脂、彩色电影胶片偶联剂等的生产。
氯丙酮名称
[ CAS 号 ]:
78-95-5
[ 中文名 ]:
一氯丙酮
[ 英文名 ]:
Chloroacetone
[中文别名 ]:
[英文别名 ]:
- Tonite
- MFCD00000936
- Chloro acetone
- 1-Chloroacetone
- Chloropropanone
- 2-Propanone,1-chloro
- Chloroacetone
- Acetonyl chloride
- Chloracetone
- 2-Propanone, 1-chloro-
氯丙酮物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
120.0±8.0 °C at 760 mmHg
[ 熔点 ]:
-44.5 °C
[ 分子式 ]:
C3H5ClO
[ 分子量 ]:
92.524
[ 闪点 ]:
27.8±0.0 °C
[ 精确质量 ]:
92.002892
[ PSA ]:
17.07000
[ LogP ]:
0.43
[ 外观性状 ]:
无色至暗黄色液体
[ 蒸汽压 ]:
15.5±0.2 mmHg at 25°C
[ 折射率 ]:
1.397
[ 储存条件 ]:
库房通风低温干燥,防明火,防高温,与食品原料,氧化剂分开储运
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases. May discolour on exposure to light. STENCH.
[ 水溶解性 ]:
124 g/L (20 ºC)
氯丙酮MSDS
氯丙酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC0700000
- CHEMICAL NAME :
- 2-Propanone, 1-chloro-
- CAS REGISTRY NUMBER :
- 78-95-5
- BEILSTEIN REFERENCE NO. :
- 0605369
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C3-H5-Cl-O
- MOLECULAR WEIGHT :
- 92.53
- WISWESSER LINE NOTATION :
- G1V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 605 ppm/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 262 ppm/1H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 127 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 141 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 650 mg/kg/17D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 100 pph/6M
- REFERENCE :
- PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74. Volume(issue)/page/year: 62,284,1946/1947 *** REVIEWS *** ACGIH TLV-CL 3.8 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5194 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
氯丙酮安全信息
[ 符号 ]:
GHS02, GHS06, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H226-H301-H310 + H330-H315-H319-H335-H410
[ 警示性声明 ]:
P260-P273-P280-P284-P301 + P310-P302 + P350
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;
[ 风险声明 (欧洲) ]:
R10;R24/25;R26;R36/37/38;R50/53
[ 安全声明 (欧洲) ]:
S16-S23-S36/37/39-S45-S60-S61-S38-S28A-S26
[ 危险品运输编码 ]:
UN 1695 6.1/PG 1
[ WGK德国 ]:
3
[ RTECS号 ]:
UC0700000
[ 包装等级 ]:
I
[ 危险类别 ]:
6.1
氯丙酮合成路线
氯丙酮上下游产品
氯丙酮上游产品
氯丙酮下游产品
氯丙酮制备
1.丙酮氯化法 丙酮和碳酸钙搅拌形成浆状,加热回流,停止加热后通入氯气,约3-4小时后,加水使生成的氯化钙溶解,反应液分成两层,收集油层,然后精制,得成品。
2.丙酮非氯气氯化法 以丙酮为原料,由氯酸钾等氧化剂与氯化氢反应分解产生的氯气氯化而得。
3.氯代三聚氰酸法 以三氯三聚氰酸为卤化剂,以硫酸水溶液为催化剂,对丙酮进行氯化反应而得。该工艺是国外90年代初的工艺,其合成方法简便,产品含量高。
氯丙酮文献
Molecules 17(8) , 9335-47, (2012)
Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-ones 5a-h, via reactions...
[Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. VI. 4-(o-tolyl)-thiosemicarbazide of o-nitro - and p-nitrobenzoic acid].Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 195-202, (1996)
The reactions of 4-(o-tolyl)-thiosemicarbazide of o-nitro- and p-nitrobenzoic acid (Ik, l) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanolic...
[Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. V. 4-(o-tolyl)-thiosemicarbazide of of o-chloro- and p-chlorobenzoic acid].Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 185-93, (1996)
The reactions of 4-(o-tolyl)-thiosemicarbazide of o-chloro- and p-chlorobenzoic acid (Ii, j) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanol...
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