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五甲基哌啶

五甲基哌啶用途

Pempidine是一类神经节阻断药物,口服能够治疗高血压。

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五甲基哌啶名称

[ CAS 号 ]:
79-55-0

[ 中文名 ]:
1,2,2,6,6-五甲基哌啶

[ 英文名 ]:
Pempidine

[中文别名 ]:

潘必定

[英文别名 ]:

PIPERIDINE,1,2,2,6,6-PENTAMETHYL
Pyrilene
MFCD00006493
N-methyl-2,2,6,6-tetramethylpiperidine
Perolysen
EINECS 201-211-2
M+B 4486
Pempidine
N,2,2,6,6-pentamethyl piperidine

五甲基哌啶生物活性

[ 描述 ]:

Pempidine是一类神经节阻断药物,口服能够治疗高血压。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51.

[2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )

[相关活性小分子]

五甲基哌啶物理化学性质

[ 密度 ]:
0.858 g/mL at 25 °C(lit.)

[ 沸点 ]:
187-188 °C(lit.)

[ 熔点 ]:
137-141ºC

[ 分子式 ]:
C₁₀H₂₁N

[ 分子量 ]:
155.28000

[ 闪点 ]:
122 °F

[ 精确质量 ]:
155.16700

[ PSA ]:
3.24000

[ LogP ]:
2.59720

[ 外观性状 ]:
无色-淡黄色透明液体

[ 折射率 ]:
n20/D 1.460(lit.)

[ 储存条件 ]:
Flammables area

五甲基哌啶MSDS

五甲基哌啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN2190000

CHEMICAL NAME :: Piperidine, 1,2,2,6,6-pentamethyl-

CAS REGISTRY NUMBER :: 79-55-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H21-N

MOLECULAR WEIGHT :: 155.32

WISWESSER LINE NOTATION :: T6NTJ A1 B1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

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五甲基哌啶安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R10

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
UN 1992 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
TN2190000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2933399090

五甲基哌啶合成路线

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五甲基哌啶下游产品

五甲基哌啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

五甲基哌啶文献

Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.

Neurochem. Res. 21(9) , 1141-8, (1996)

The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase i...

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.

Brain Res. 444(1) , 189-94, (1988)

Both presynaptic and postsynaptic blockade of ganglionic transmission during the period of naturally occurring ganglion cell death reduced the number of surviving neurons in the sympathetic ganglia (S...

Understanding channel blocking in the nicotinic acetylcholine receptor.

Receptors Channels 7(4) , 273-88, (2001)

Ion-channel blockers are molecules that obstruct the path used by ions to cross the membrane through a protein channel. Many of these are local anesthetics, toxins or drugs of abuse, and the knowledge...

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