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双琥珀酰亚胺戊二酸酯

双琥珀酰亚胺戊二酸酯用途

DSG Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。

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双琥珀酰亚胺戊二酸酯名称

[ CAS 号 ]:
79642-50-5

[ 中文名 ]:
双琥珀酰亚胺戊二酸酯

[ 英文名 ]:
DSG Crosslinker

[中文别名 ]:

二(N-羟基琥珀酰亚胺)戊二酸酯

[英文别名 ]:

N,N'-disuccinimidyl glutarate
DISUCCINIMIDYL GLUTARATE

双琥珀酰亚胺戊二酸酯生物活性

[ 描述 ]:

DSG Crosslinker 是一种可降解 (cleavable) 的 ADC linker,用于合成可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

研究领域 >> 炎症/免疫

[ 靶点 ]

Cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接物连接ADC细胞毒素。

[参考文献]

[1]. Geng X, et al. Synthesis of the Oligosaccharides of Burkholderia pseudomallei and B. mallei Capsular Polysaccharide and Preliminary Immunological Studies of Their Protein Conjugates. J Org Chem. 2020 Feb 21;85(4):2369-2384.

双琥珀酰亚胺戊二酸酯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
485.1±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₄N₂O₈

[ 分子量 ]:
326.259

[ 闪点 ]:
247.2±31.5 °C

[ 精确质量 ]:
326.075012

[ PSA ]:
127.36000

[ LogP ]:
-3.30

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.572

[ 储存条件 ]:
-20°C

双琥珀酰亚胺戊二酸酯MSDS

双琥珀酰亚胺戊二酸酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

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双琥珀酰亚胺戊二酸酯文献

New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.

Biochimie 118 , 1-7, (2015)

The eukaryotic translation elongation factor 1A (eEF1A) is a moonlighting protein that besides to its canonical role in protein synthesis is also involved in many other cellular processes such as cell...

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Nat. Commun. 6 , 6285, (2015)

STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that S...

The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.

Sci. Rep. 5 , 9059, (2015)

The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the role of Nr4a1 in CD8(+) T...

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