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5α-cholest-7-en-3ß-ol

5α-cholest-7-en-3ß-ol用途

Lathosterol 是一种胆固醇样分子。血清 Lathosterol 浓度是全身胆固醇合成的指标。

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5α-cholest-7-en-3ß-ol名称

[ CAS 号 ]:
80-99-9

[ 中文名 ]:
5α-cholest-7-en-3ß-ol

[ 英文名 ]:
Lathosterol

[英文别名 ]:

Cholest-7-en-3beta-ol
Cholest-7-en-3-ol
5alpha-Cholest-7-en-3beta-ol
5alpha-cholest-7-en-3beta-ol
7-cholestenol
Lathosterol

5α-cholest-7-en-3ß-ol生物活性

[ 描述 ]:

Lathosterol 是一种胆固醇样分子。血清 Lathosterol 浓度是全身胆固醇合成的指标。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 类固醇

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Kempen HJ, et al. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res. 1988 Sep;29(9):1149-55.

[相关活性小分子]

5α-cholest-7-en-3ß-ol物理化学性质

[ 密度 ]:
0.98 g/cm3

[ 沸点 ]:
479.4ºC

[ 分子式 ]:
C₂₇H₄₆O

[ 分子量 ]:
386.65400

[ 闪点 ]:
208.9ºC

[ 精确质量 ]:
386.35500

[ PSA ]:
20.23000

[ LogP ]:
7.38870

[ 折射率 ]:
1.525

[ 储存条件 ]:
2-8℃

5α-cholest-7-en-3ß-olMSDS

5α-cholest-7-en-3ß-ol毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ7000000

CHEMICAL NAME :: 5-alpha-Cholest-7-en-3-beta-ol

CAS REGISTRY NUMBER :: 80-99-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H46-O

MOLECULAR WEIGHT :: 386.73

WISWESSER LINE NOTATION :: L E5 B666 IUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 19,977,1957

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5α-cholest-7-en-3ß-ol安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FZ7000000

5α-cholest-7-en-3ß-ol合成路线

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5α-cholest-7-en-3ß-ol文献

Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(32) , 3806-11, (2011)

Phytosterols (PS; β-sitosterol and campesterol) and cholesterol precursors (CP; desmosterol and lathosterol) have been suggested as important biochemical markers of cholesterol intestinal absorption a...

Serum lipid responses to weight loss differ between overweight adults with familial hypercholesterolemia and those with familial combined hyperlipidemia.

J. Nutr. 144(8) , 1219-26, (2014)

The effect of weight loss on lipids differs among individuals, although whether it can modify the management of hereditary hyperlipidemias has not yet been explored. The objective of this study was to...

Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients

Atherosclerosis 225(2) , 388-96, (2012)

Objective Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates sy...

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