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邻甲基水杨酸

邻甲基水杨酸用途

3-Methylsalicylic acid是一种水杨酸衍生物, 作用于人血浆, 通过激活纤维蛋白溶解系统, 而具有显著的纤溶活性。

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邻甲基水杨酸名称

[ CAS 号 ]:
83-40-9

[ 中文名 ]:
3-甲基水杨酸

[ 英文名 ]:
3-Methylsalicylic acid

[中文别名 ]:

[英文别名 ]:

Cresotic acid
2-carboxy-6-methylphenol
o-cresotic acid
o-cresotinic
Hydroxytoluic
EINECS 209-447-8
2-Hydroxy-3-methyl-benzoic acid
3-Methylsalicylic acid
Benzoic acid, 2-hydroxy-3-methyl-
2-ANISIC ACID

邻甲基水杨酸生物活性

[ 描述 ]:

3-Methylsalicylic acid是一种水杨酸衍生物, 作用于人血浆, 通过激活纤维蛋白溶解系统, 而具有显著的纤溶活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[相关活性小分子]

邻甲基水杨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
293.2±28.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
145.4±20.5 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
2.52

[ 外观性状 ]:
白色至略微红的结晶固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
-20?C Freezer

[ 水溶解性 ]:
1.5 g/L (20 ºC)

邻甲基水杨酸MSDS

邻甲基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP3920000

CHEMICAL NAME :: 2,3-Cresotic acid

CAS REGISTRY NUMBER :: 83-40-9

BEILSTEIN REFERENCE NO. :: 2086811

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QVR BQ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 445 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - analgesia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

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邻甲基水杨酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R41

[ 安全声明 (欧洲) ]:
S26-S36/39-S22

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ4385000

[ 海关编码 ]:
2918290000

邻甲基水杨酸合成路线

邻甲基水杨酸上下游产品

邻甲基水杨酸上游产品

邻甲基水杨酸下游产品

邻甲基水杨酸制备

它的生产有固相法和溶剂法，两者相比后者不需要处理吸湿性很强的邻甲酚钠盐干粉末。反应物料系液相碳羧化反应时通CO2一次完成，不需中途蒸酚，在普通的压力设备中便能进行生产，减少了使用脱水和碳羧化设备。两种方法的生产原理是相同的。

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邻甲基水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

邻甲基水杨酸文献

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling

J. Chromatogr. A. 1218(23) , 3689-94, (2011)

We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of io...

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

Bioorg. Med. Chem. 16 , 9101-5, (2008)

The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and II, with a series of salicylic acid derivatives was investigated by using the esterase method with 4-nitr...

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邻甲基水杨酸

邻甲基水杨酸用途

邻甲基水杨酸名称

邻甲基水杨酸生物活性

邻甲基水杨酸物理化学性质

邻甲基水杨酸MSDS

详细MSDS(安全技术说明书)

邻甲基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

邻甲基水杨酸安全信息

邻甲基水杨酸合成路线

详细合成路线

邻甲基水杨酸上下游产品

邻甲基水杨酸上游产品

邻甲基水杨酸下游产品

邻甲基水杨酸制备

邻甲基水杨酸海关

邻甲基水杨酸文献

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