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伏格列波糖

伏格列波糖用途

Voglibose是valiolamine的衍生物,能很好的抑制α-葡萄糖苷酶,可作用于高血糖症等。

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伏格列波糖名称

[ CAS 号 ]:
83480-29-9

[ 中文名 ]:
伏格列波糖

[ 英文名 ]:
Voglibose

[中文别名 ]:

伏利多糖

[英文别名 ]:

Beigrace
Jumeal
Voglibose
Glustat
Voglibose (JP15/USAN)
Basen
Voglistat
AO 128
MFCD00865496
N-(1,3-Dihydroxy-2-propyl)valiolamine

伏格列波糖生物活性

[ 描述 ]:

Voglibose是valiolamine的衍生物,能很好的抑制α-葡萄糖苷酶,可作用于高血糖症等。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Chen, X., Y. Zheng, and Y. Shen, Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors. Curr Med Chem, 2006. 13(1): p. 109-16.

[2]. Ikenoue, T., et al., Effect of a new hypoglycemic agent, A-4166 [(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenclamide. Biol Pharm Bull, 1997. 20(4): p. 354-9.

[3]. Moritoh, Y., K. Takeuchi, and M. Hazama, Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice. Diabetes Obes Metab, 2010. 12(3): p. 224-33.

[相关活性小分子]

伏格列波糖物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
601.9±55.0 °C at 760 mmHg

[ 熔点 ]:
162-163ºC

[ 分子式 ]:
C₁₀H₂₁NO₇

[ 分子量 ]:
267.276

[ 闪点 ]:
274.1±22.1 °C

[ 精确质量 ]:
267.131805

[ PSA ]:
153.64000

[ LogP ]:
-2.36

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±3.9 mmHg at 25°C

[ 折射率 ]:
1.636

[ 储存条件 ]:
Store at -20°C

伏格列波糖MSDS

详细MSDS(安全技术说明书)

伏格列波糖安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NM7524600

伏格列波糖合成路线

详细合成路线

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伏格列波糖文献

Intensive glucose lowering in cardiovascular risk management - unsolved questions - .

Circ. J. 76(3) , 593-5, (2012)

Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients.

Circ. J. 76(3) , 712-20, (2012)

Postprandial hyperglycemia and hyperinsulinemia have been considered as important determinants for the development of atherosclerosis. However, it remains to be elucidated whether correction of the po...

Effect of voglibose on the pharmacokinetics of metformin in healthy Korean subjects.

Int. J. Clin. Pharmacol. Ther. 52(11) , 1005-11, (2014)

The objective of this study was to evaluate the effects of voglibose on the pharmacokinetics of metformin.A randomized, open-label, two-way crossover study with a 7-day washout period was conducted. A...

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