硬骨鱼紧张肽 I

硬骨鱼紧张肽 I用途

Urotensin I 是由 41 个氨基酸组成的神经肽，结构与 CRF 类似，可与 CRF 受体结合，在细胞实验中，对人 CRF₁，CRF₂ 和大鼠 CRF_2α 受体的 pEC₅₀ 值分别为 11.46，9.36 和 9.85，对 hCRF₁，rCRF_2α 和 mCRF_2β 受体的 K_i 值分别为 0.4，1.8 和 5.7 nM。

点击显示

硬骨鱼紧张肽 I名称

[ CAS 号 ]:
83930-33-0

[ 中文名 ]:
硬骨鱼紧张肽 I

[ 英文名 ]:
Urotensin I

[英文别名 ]:

Catostomus urotensin I

硬骨鱼紧张肽 I生物活性

[ 描述 ]:

Urotensin I 是由 41 个氨基酸组成的神经肽,结构与 CRF 类似,可与 CRF 受体结合,在细胞实验中,对人 CRF1,CRF2 和大鼠 CRF2α 受体的 pEC50 值分别为 11.46,9.36 和 9.85,对 hCRF1,rCRF2α 和 mCRF2β 受体的 Ki 值分别为 0.4,1.8 和 5.7 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR

研究领域 >> 心血管疾病

多肽产品

[ 靶点 ]

pEC50: 11.46 (human CRF1, CHO cells), 9.36 (human CRF2, CHO cells), 9.85 (rat CRF2α, CHO cells)[1] Ki: 0.4 nM (hCRF1, cell assay), 1.8 nM (rCRF2α, cell assay), and 5.7 nM (mCRF2β, cell assay)[2]

[体外研究]

Urotensin I是一种41-aa神经肽,作为CRF受体的激动剂,CHO细胞中人CRF1,人CRF2和大鼠CRF2α受体的pEC50分别为11.46,9.36和9.85,Kis为0.4,1.8和5.7 nM分别为细胞试验中的hCRF1,rCRF2α和mCRF2β受体[2]。 Urotensin I与绵羊促肾上腺皮质激素释放因子和青蛙沙瓦金具有显着的序列同源性,具有强效的降血压活性和促肾上腺皮质激素释放活性[3]。 Urotensin I刺激从孤立的分散的金鱼垂体前叶细胞柱释放ACTH [4]。

[参考文献]

[1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.

[2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.

[3]. Lederis K, et al. Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from Catostomus. Science. 1982 Oct 8;218(4568):162-5.

[4]. Fryer J, et al. Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary. Endocrinology. 1983 Dec;113(6):2308-10.

[相关活性小分子]

硬骨鱼紧张肽 I物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
1402.8±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁₀H₃₄₀N₆₂O₆₇S₂

[ 分子量 ]:
4869.46

[ 闪点 ]:
802.2±34.3 °C

[ LogP ]:
-4.51

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.669

硬骨鱼紧张肽 I安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

硬骨鱼紧张肽 I文献

Differential expression of corticotropin-releasing factor (CRF) and urotensin I precursor genes, and evidence of CRF gene expression regulated by cortisol in goldfish brain.

Gen. Comp. Endocrinol. 116 , 461-477, (1999)

Corticotropin-releasing factor (CRF) and urotensin I (UI) precursor cDNAs were cloned and sequenced from a goldfish brain cDNA library in order to investigate the distribution of CRF and UI mRNAs in g...

Cardiovascular actions of centrally and peripherally administered trout urotensin-I in the trout.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 , R484-R491, (2000)

The cardiovascular effects of centrally and peripherally administered synthetic trout urotensin (U)-I, a member of the corticotropin-releasing hormone family of neuroendocrine peptides, were investiga...

Singular contributions of fish neuroendocrinology to mammalian regulatory peptide research.

Regul. Pept. 93 , 3-12, (2000)

During the past 20 years, several bioactive peptides have been identified in teleost fishes that subsequently have been shown to play important regulatory roles in mammalian physiology. The urophysis,...

更多文献