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胃膜素

胃膜素用途

Gastric mucin 是一种大的糖蛋白,保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤的影响。

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胃膜素名称

[ CAS 号 ]:
84082-64-4

[ 中文名 ]:
胃膜素

[ 英文名 ]:
Gastric mucin

[中文别名 ]:

[英文别名 ]:

Gastric Mucin
EINECS 282-010-7

胃膜素生物活性

[ 描述 ]:

Gastric mucin 是一种大的糖蛋白,保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤的影响。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

多肽产品

[体外研究]

胃粘蛋白可能与幽门螺杆菌引起的胃粘膜损伤机制有关,导致胃炎,消化性溃疡,可能还有胃癌[1]。胃粘蛋白根据其组织化学特性分为两类。第一种是表面粘液细胞型粘蛋白,由表面粘液细胞分泌。第二种发现于粘膜的较深部分,由腺体粘液细胞分泌,包括粘液颈细胞,心脏腺细胞和幽门腺细胞。胃粘蛋白中独特的O-聚糖似乎起到天然抗生素的作用,保护宿主免受幽门螺杆菌感染[2]。胃粘蛋白可通过清除腔内产生的氧化剂来保护表面上皮胃肠道;然而,它是以牺牲其粘弹性为代价的。天然和链霉蛋白酶处理的粘蛋白均有效清除羟基自由基,并且清除特性没有显着差异。对于天然和链霉蛋白酶处理的粘蛋白,丙二醛产量减少50％所需的粘蛋白有效浓度为10 mg/mL [3]。

[参考文献]

[1]. Toribara NW, et al. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem. 1993 Mar 15;268(8):5879-85.

[2]. Kawakubo M, et al. Natural antibiotic function of a human gastric mucin against Helicobacter pyloriinfection. Science. 2004 Aug 13;305(5686):1003-6.

[3]. Grisham MB, et al. Interaction between oxygen radicals and gastric mucin. Am J Physiol. 1987 Jul;253(1 Pt 1):G93-6.

[相关活性小分子]

胃膜素物理化学性质

[ 外观性状 ]:
partially purified powder

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
1 M NaOH: soluble20mg/mL

胃膜素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

胃膜素文献

Oral bioaccessibility of arsenic, mercury and methylmercury in marine species commercialized in Catalonia (Spain) and health risks for the consumers.

Food Chem. Toxicol. 86 , 34-40, (2015)

This study was aimed at characterizing the bioaccessibility of arsenic (As), mercury (Hg) and methylmercury (MeHg) in commercial fish and seafood species widely consumed by the population of Catalonia...

Characterization of novel beta-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae.

Infect. Immun. 78(1) , 348-57, (2010)

The pneumococcus obtains its energy from the metabolism of host glycosides. Therefore, efficient degradation of host glycoproteins is integral to pneumococcal virulence. In search of novel pneumococca...

Effect of broccoli phytochemical extract on release of fatty acids from salmon muscle and salmon oil during in vitro digestion.

Food Funct. 5(9) , 2331-7, (2014)

The aim of the present work was to study the effect of a broccoli phytochemical extract (Br-ex) on the release of fatty acids (FA) from salmon muscle (SM) and salmon oil (SO) during in vitro digestion...

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胃膜素

胃膜素用途

胃膜素名称

胃膜素生物活性

胃膜素物理化学性质

胃膜素安全信息

胃膜素文献

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