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福辛普利钠

福辛普利钠用途

Fosinopril钠是血管紧张素转换酶(ACE)抑制剂的原药,可作用于高血压和慢性心力衰竭。

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福辛普利钠名称

[ CAS 号 ]:
88889-14-9

[ 中文名 ]:
福辛普利钠

[ 英文名 ]:
Fosinopril sodium

[中文别名 ]:

蒙诺(福辛普利那)

[英文别名 ]:

Tensozide
Dynacil
Fosinopril sodium
Fosinorm
Staril
MFCD00897699
Fositen
Fozitec
Elidur

福辛普利钠生物活性

[ 描述 ]:

Fosinopril钠是血管紧张素转换酶(ACE)抑制剂的原药,可作用于高血压和慢性心力衰竭。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

天然产物 >> 生物碱

研究领域 >> 心血管疾病

[参考文献]

[1]. Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77(6 Pt 2): p. I74-8.

[2]. Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7.

[3]. Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6(4): p. 181-9.

[相关活性小分子]

福辛普利钠物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
705.7±70.0 °C at 760 mmHg

[ 熔点 ]:
196-198ºC

[ 分子式 ]:
C₃₀H₄₅NNaO₇P

[ 分子量 ]:
563.662

[ 闪点 ]:
380.6±35.7 °C

[ 精确质量 ]:
563.301208

[ PSA ]:
122.85000

[ LogP ]:
6.09

[ 外观性状 ]:
白色至灰白色结晶固体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
-20°C Freezer

福辛普利钠MSDS

详细MSDS(安全技术说明书)

福辛普利钠安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

福辛普利钠海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

福辛普利钠文献

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

Clin. Pharmacol. Ther. 96(6) , 713-22, (2014)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a...

Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.

Pharmacol. Res. 65(3) , 285-96, (2012)

The renin-angiotensin system (RAS) exists in the brain and it may be involved in pathogenesis of neurological and psychiatric disorders including seizures. The aim of the present research was to evalu...

Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk.

Am. J. Cardiol. 108(2) , 294-301, (2011)

The renin-angiotensin system is an important mediator of tumor progression and metastasis. A recent meta-analysis of randomized controlled trials reported an increased risk of cancer with angiotensin ...

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