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培哚普利

培哚普利用途

Perindopril是长效血管紧张素转换酶(ACE)抑制剂。

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培哚普利名称

[ CAS 号 ]:
107133-36-8

[ 中文名 ]:
培哚普利叔丁胺盐

[ 英文名 ]:
Perindopril erbumine

[中文别名 ]:

[英文别名 ]:

Aceon
S 9490-3
PrestariuM
McN-A 2833-109
McN-A-2833-109
Perinodpril ErbiMune
ButylaMiniperindopril
Perindoril
Perindopril erbumine
MFCD02313824

培哚普利生物活性

[ 描述 ]:

Perindopril是长效血管紧张素转换酶(ACE)抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

研究领域 >> 心血管疾病

[参考文献]

[1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.

[2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

[相关活性小分子]

培哚普利物理化学性质

[ 密度 ]:
1.15 g/cm3

[ 沸点 ]:
537.4ºC at 760mmHg

[ 熔点 ]:
126-128ºC

[ 分子式 ]:
C₂₃H₄₃N₃O₅

[ 分子量 ]:
441.605

[ 闪点 ]:
278.8ºC

[ 精确质量 ]:
441.320282

[ PSA ]:
121.96000

[ LogP ]:
3.71330

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
H2O: soluble10mg/mL, clear

培哚普利安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NL5999600

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培哚普利文献

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

Clin. Pharmacol. Ther. 96(6) , 713-22, (2014)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a...

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.

Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014)

Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early ons...

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Drug Metab. Dispos. 42(9) , 1522-31, (2014)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr...

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