N,N-二乙基苯胺

N,N-二乙基苯胺用途

【用途一】
用于染料中间体、乳胶促进剂、制药、农药等
【用途二】
用作分析试剂，也用于有机合成
【用途三】
二乙基苯胺主要用于生产偶氮染料，三苯基甲烷染料，可制备碱性艳绿、碱性紫、酸性湖蓝V等；也是制药工业、彩色影片显影剂的中间体。用作分析试剂和检测锌和锰。
【用途四】
用作分析试剂和检测锌和锰。

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N,N-二乙基苯胺名称

[ CAS 号 ]:
91-66-7

[ 中文名 ]:
N,N-二乙基苯胺

[ 英文名 ]:
N,N-Diethylaniline

[中文别名 ]:

[英文别名 ]:

EINECS 202-088-8
Aniline,N,N-diethyl
N,N-diethylbenzeneamine
2N2&R
N,N-Diethylaniline
N,N-Diethylanilin
MFCD00009042
N,N-Diethylbenzenamine
Benzenamine, N,N-diethyl-
Diethylphenylamine

N,N-二乙基苯胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
213.5±9.0 °C at 760 mmHg

[ 熔点 ]:
-38 °C

[ 分子式 ]:
C₁₀H₁₅N

[ 分子量 ]:
149.233

[ 闪点 ]:
97.8±0.0 °C

[ 精确质量 ]:
149.120453

[ PSA ]:
3.24000

[ LogP ]:
3.39

[ 外观性状 ]:
淡黄色至棕色液体

[ 蒸汽密度 ]:
5.2 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
库房通风低温干燥,与酸类、氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids.

[ 水溶解性 ]:
14 g/L (12 ºC)

N,N-二乙基苯胺MSDS

N,N-二乙基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX3400000

CHEMICAL NAME :: Aniline, N,N-diethyl-

CAS REGISTRY NUMBER :: 91-66-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H15-N

MOLECULAR WEIGHT :: 149.26

WISWESSER LINE NOTATION :: 2N2&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0430

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 15,447,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(6),22,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83987 No. of Facilities: 514 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2387 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83987 No. of Facilities: 302 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 3640 (estimated) No. of Female Employees: 777 (estimated)

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N,N-二乙基苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H373-H411

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R51/53

[ 安全声明 (欧洲) ]:
S28-S37-S45-S61-S28A

[ 危险品运输编码 ]:
UN 2432 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
BX3400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921420090

N,N-二乙基苯胺合成路线

N,N-二乙基苯胺上下游产品

N,N-二乙基苯胺上游产品

N,N-二乙基苯胺下游产品

N,N-二乙基苯胺制备

1.氯乙烷法由苯胺与氯乙烷反应而得。因反应过程放热，当体系反应温度120℃、1.18MPa时停止加热；维持反应3h，锅内温度可达215-230℃，压力4.4-4.5MPa。泄压后水蒸气蒸馏，得粗品。根据粗品中一乙基苯胺的含量，加入苯酐酰化，再进行第二次水蒸气蒸馏，馏出物除水后即为成品。原料消耗（kg/t):苯胺645，氯乙烷（95%）1473，烧碱（42%）1230，苯酐29。 2.溴乙烷法：在装有电动搅拌器、温度计、回流冷凝器的500ml四颈反应烧瓶中，加入11ml（0.12mol）苯胺、15.75ml(0.21mol)溴乙烷、1.00g苄基三乙基氯化铵、35ml质量分数为0.35的氢氧化钠溶液，加热控制反应瓶内温度为45℃，常压下搅拌反应3h；冷却至室温，将反应液倒入分液漏斗中，静置分层。将油、水两层分离；水层用30ml乙醚分3次萃取，萃取液与油层混合。用无水硫酸镁干燥3h,过滤、蒸出乙醚。用等体积的乙酸酐处理剩佘物并保持过夜，以除去游离的仲胺。再加入质量分数为0.1的过量盐酸溶液，洗涤至酸性（PH=1-2），分出乙酰-N-乙基苯胺，用质量分数为0.25的氢氧化钠溶液碱化到PH=11-12，静置分层，分离油水两层。水层用30ml乙醚萃取2次。将萃取液与油层混合，用无水硫酸镁干燥3h，蒸去乙醚后减压蒸馏，收集沸点62-66℃/400pa的馏分，得N，N-二乙基苯胺11.18g，收率70.4%。 3.精制方法：主要杂质是N-乙基苯胺，可以通过蒸馏分离，或者将N-乙基苯胺酰基化，由于N-乙基苯胺的酰基化物挥发性低，故可将N,N-二乙基苯胺蒸馏出来。 4.亚磷酸二乙酯法：由苯胺与亚磷酸二乙酯在常压下反应而得。

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N,N-二乙基苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N,N-二乙基苯胺文献

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.

Biochem. Pharmacol. 93(2) , 171-81, (2015)

Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms o...

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Exploring the enantioseparation of amino-naphthol analogues by supercritical fluid chromatography.

J. Chromatogr. A. 1387 , 123-33, (2015)

The direct separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol, 2-(α-aminoarylmethyl)-1-naphthol analogues and 2-(1-amino-2-methylpropyl)-1-naphthol) was inv...

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N,N-二乙基苯胺

N,N-二乙基苯胺用途

N,N-二乙基苯胺名称

N,N-二乙基苯胺物理化学性质

N,N-二乙基苯胺MSDS

详细MSDS(安全技术说明书)

N,N-二乙基苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N,N-二乙基苯胺安全信息

N,N-二乙基苯胺合成路线

详细合成路线

N,N-二乙基苯胺上下游产品

N,N-二乙基苯胺上游产品

N,N-二乙基苯胺下游产品

N,N-二乙基苯胺制备

N,N-二乙基苯胺海关

N,N-二乙基苯胺文献

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