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头孢丙烯

头孢丙烯用途

头孢丙烯(Cefprozil)是第二代头孢菌素类抗生素[1]。

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头孢丙烯名称

[ CAS 号 ]:
92665-29-7

[ 中文名 ]:
头孢丙烯

[ 英文名 ]:
(Z)-Cefprozil

[中文别名 ]:

[英文别名 ]:

Cefprozil
Prozef
Cefrozil
CEFPROZIL , (Z)-
Cephprozyl
MFCD00865082

头孢丙烯生物活性

[ 描述 ]:

头孢丙烯(Cefprozil)是第二代头孢菌素类抗生素[1]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

头孢丙烯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
803.1±65.0 °C at 760 mmHg

[ 熔点 ]:
76°C

[ 分子式 ]:
C₁₈H₁₉N₃O₅S

[ 分子量 ]:
389.426

[ 闪点 ]:
439.5±34.3 °C

[ 精确质量 ]:
389.104553

[ PSA ]:
158.26000

[ LogP ]:
0.06

[ 外观性状 ]:
白色至黄色结晶粉末

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.718

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
3.3 mg/L (20 ºC)

头孢丙烯MSDS

详细MSDS(安全技术说明书)

头孢丙烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0339000

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-8-oxo-3-(1-propenyl)-, (6R-(6-alpha,7-beta(R*)))-, hydrate

CAS REGISTRY NUMBER :: 92665-29-7

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H19-N3-O5-S.H2-O

MOLECULAR WEIGHT :: 407.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 100 mg/kg/5D-I

TOXIC EFFECTS :: Musculoskeletal - joints Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 7500 ug/kg/5D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Musculoskeletal - joints Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1243,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14 gm/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1260,1990

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头孢丙烯安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
XZ4380000

[ 海关编码 ]:
2941905990

头孢丙烯海关

[ 海关编码 ]: 2941905990