6-氮杂胸腺嘧啶

6-氮杂胸腺嘧啶用途

6-Azathymine,胸腺嘧啶的 6-氮类似物,是一种有效的 D-3-氨基异丁酸酯-丙酮酸氨基转移酶 (D-3-aminoisobutyrate-pyruvate aminotransferase) 抑制剂。6-Azathymine 可抑制 DNA 的生物合成,并具有抗菌和抗病毒活性。

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6-氮杂胸腺嘧啶名称

[ CAS 号 ]:
932-53-6

[ 中文名 ]:
6-氮杂胸腺嘧啶

[ 英文名 ]:
6-Azathymine

[中文别名 ]:

[英文别名 ]:

6-Methyl-2H-[1,2,4]triazin-3,5-dion
USAF CB-28
1,2,4-triazine-3,5-diol, 6-methyl-
Azathymine
6-methyl-2H-[1,2,4]triazine-3,5-dione
Azathymine,6
6-azathymine
1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl
6-methyl-2H-[1,2,4]triazin-3,5-dione
6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione

6-氮杂胸腺嘧啶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

信号通路 >> 抗感染 >> 细菌

[体外研究]

6-氮杂胸腺嘧啶是粪链球菌(8043)和其他几种微生物菌株生长的竞争性拮抗剂。对6-氮杂胸腺嘧啶作用机理的研究表明,粪链球菌可以将类似物转化为相应的脱氧核糖苷,氮杂胸苷[2]。

[参考文献]

[1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45.

[2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14.

[3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36.

[4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220.

6-氮杂胸腺嘧啶物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 熔点 ]:
210-212°C

[ 分子式 ]:
C₄H₅N₃O₂

[ 分子量 ]:
127.101

[ 精确质量 ]:
127.038177

[ PSA ]:
78.61000

[ LogP ]:
-2.05

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 折射率 ]:
1.692

[ 储存条件 ]:
室温

6-氮杂胸腺嘧啶MSDS

6-氮杂胸腺嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY8050000

CHEMICAL NAME :: as-Triazine-3,5(2H,4H)-dione, 6-methyl-

CAS REGISTRY NUMBER :: 932-53-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H5-N3-O2

MOLECULAR WEIGHT :: 127.12

WISWESSER LINE NOTATION :: T6NMVMVJ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

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6-氮杂胸腺嘧啶安全信息

[ 安全声明 (欧洲) ]:
S22-S24/25

[ RTECS号 ]:
XY8050000

[ 海关编码 ]:
2933699090

6-氮杂胸腺嘧啶合成路线

6-氮杂胸腺嘧啶上下游产品

6-氮杂胸腺嘧啶上游产品

6-氮杂胸腺嘧啶下游产品

6-氮杂胸腺嘧啶海关

[ 海关编码 ]: 2933699090

[ 中文概述 ]:
2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%