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1,3-二甲基尿酸

1,3-二甲基尿酸用途

1,3-Dimethyluric acid 是人体茶碱代谢的产物。1,3-Dimethyluric acid 是尿路结石中的嘌呤成分之一。

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1,3-二甲基尿酸名称

[ CAS 号 ]:
944-73-0

[ 中文名 ]:
1,3-二甲基尿酸

[ 英文名 ]:
1,3-Dimethyluric acid

[中文别名 ]:

1,3-二甲基-2,6,8-三羟基嘌呤

[英文别名 ]:

EINECS 213-410-1
1,3-DIMETHYLURIC ACID
MFCD00009740

1,3-二甲基尿酸生物活性

[ 描述 ]:

1,3-Dimethyluric acid 是人体茶碱代谢的产物。1,3-Dimethyluric acid 是尿路结石中的嘌呤成分之一。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

1,3-二甲基尿酸物理化学性质

[ 密度 ]:
1.63g/cm3

[ 沸点 ]:
520.2ºC at 760mmHg

[ 熔点 ]:
≥300ºC(lit.)

[ 分子式 ]:
C₇H₈N₄O₃

[ 分子量 ]:
196.16300

[ 闪点 ]:
268.4ºC

[ 精确质量 ]:
196.06000

[ PSA ]:
92.65000

[ 折射率 ]:
1.675

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
1 M NH4OH: soluble50mg/mL, clear to slightly hazy, colorless to faintly yellow

1,3-二甲基尿酸MSDS

1,3-二甲基尿酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0783700

CHEMICAL NAME :: 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-1,3-dimethyl-

CAS REGISTRY NUMBER :: 944-73-0

BEILSTEIN REFERENCE NO. :: 0193698

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N4-O3

MOLECULAR WEIGHT :: 196.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-43463

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-43463

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1,3-二甲基尿酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
UP0783700

[ 海关编码 ]:
2933990090

1,3-二甲基尿酸合成路线

1,3-二甲基尿酸上下游产品

1,3-二甲基尿酸上游产品

1,3-二甲基尿酸下游产品

1,3-二甲基尿酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,3-二甲基尿酸文献

Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.

Bioorg. Med. Chem. Lett. 20 , 141-4, (2010)

CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTP...

Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells.

Bioorg. Med. Chem. Lett. 15 , 1181-4, (2005)

Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (0.4 mM). Converse...

Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU.

J. Pharm. Pharmacol. 60(1) , 45-53, (2008)

The types of hepatic cytochrome P450 (CYP) isozymes responsible for the metabolism of theophylline and for the formation of 1,3-dimethyluric acid (1,3-DMU) in rats in-vivo does not seem to have been s...

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