3,4-二氯苯胺
3,4-二氯苯胺用途
用作医药、农药、染料的中间体
【用途二】
3，4-二氯苯胺是除草剂敌稗、敌草隆、利谷隆、草不隆等的中间体。
【用途三】
可作农药和染料的中间体。用于合成敌稗、利谷隆、敌草隆、灭草灵等除草剂及偶氮染料。也用作生物活性组分中间体。
3,4-二氯苯胺名称
[ CAS 号 ]:
95-76-1
[ 中文名 ]:
易瑞沙杂质III
[ 英文名 ]:
3,4-Dichloroaniline
[中文别名 ]:
[英文别名 ]:
- 3,4-DICHLORO ANILINE
- ZR CG DG
- 3,4- DICHLORO ANILINE
- 3,4-dichloro-aniline
- 3,4-DICHLOROANILINE-D2
- 4-Amino-1,2-dichlorobenzene
- Benzenamine,3,4-dichloro
- EINECS 202-448-4
- 4,5-Dichloroaniline
- 3 4 DICHLORO ANILINE
3,4-二氯苯胺物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
271.8±20.0 °C at 760 mmHg
[ 熔点 ]:
69-71 °C(lit.)
[ 分子式 ]:
C6H5Cl2N
[ 分子量 ]:
162.017
[ 闪点 ]:
118.2±21.8 °C
[ 精确质量 ]:
160.979904
[ PSA ]:
26.02000
[ LogP ]:
2.51
[ 外观性状 ]:
白色至淡黄色晶体
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.614
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂、酸类分开存放
[ 稳定性 ]:
Stable, but darkens in storage. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
[ 水溶解性 ]:
0.06 g/100 mL
3,4-二氯苯胺MSDS
3,4-二氯苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX2625000
- CHEMICAL NAME :
- Aniline, 3,4-dichloro-
- CAS REGISTRY NUMBER :
- 95-76-1
- BEILSTEIN REFERENCE NO. :
- 0636837
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C6-H5-Cl2-N
- MOLECULAR WEIGHT :
- 162.02
- WISWESSER LINE NOTATION :
- ZR CG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 545 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 675 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 675 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 237 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6370 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3640 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - alteration of classical conditioning Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 ug/m3/24H/14W-C
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 125 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 226,197,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4030 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
3,4-二氯苯胺安全信息
[ 符号 ]:
GHS05, GHS06, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H311-H317-H318-H331-H410
[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R23/24/25;R41;R43;R50/53
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S60-S61
[ 危险品运输编码 ]:
UN 3442 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
BX2625000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2921420090
3,4-二氯苯胺合成路线
3,4-二氯苯胺上下游产品
3,4-二氯苯胺上游产品
3,4-二氯苯胺下游产品
3,4-二氯苯胺制备
1.以无水三氯化铁作催化剂，向105℃的熔融状态的对硝基氯苯通入氯气，得3,4-二氯硝基苯。再在回流状态下与铁粉、甲酸和水进行还原反应，得到3,4-二氯苯胺。3,4-二氯硝基苯也可以由邻二氯苯硝化而得。在与铁粉的还原反应中可用冰醋酸代替甲酸。另一种还原方法是催化加氢法。
2.其制备方法是在反应釜中加入对氯硝基苯、无水三氯化铁催化剂，于100～110℃通入氯气，当测定氯化反应物凝固点到30～31℃时即为反应终点。将此物移至还原釜，再加入硫代硫酸钠(以消除反应物中剩余氯的影响)、甲酸，加热到100℃(回流状态)慢慢加入铁粉(约4～5h加完)，而后继续保持回流反应，当观察不到硝基苯存在时即为反应终点。加入3，4-二氯苯胺产量5～6倍的氯苯，搅拌0.5～1.0 h，经冷却、过滤并以少量氯苯洗涤滤渣，所得滤液为3，4-二氯苯胺的氯苯溶液，加热脱氯苯得3，4-二氯苯胺。
也可以用3，4-二氯硝基苯催化加氢而制得。在高压釜中加入3，4-二氯硝基苯，并加入兰尼镍催化剂，工业乙醇为溶剂，用氮气赶高压系统3次，氢气赶3次，然后充氢气达压力为4 MPa，同时升温至60～70℃进行反应，直到不吸收氢气为止，然后冷却经后处理可得成品。
此外，也可用邻二氯苯为原料，经硝化得3，4-二氯硝基苯，再进一步还原得成品。国外大部分企业用此法生产3，4-二氯苯胺。
3,4-二氯苯胺海关
[ 海关编码 ]: 2921420090
[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
3,4-二氯苯胺文献
J. Chromatogr. A. 1356 , 32-7, (2014)
In the present work, microfunnel-supported liquid-phase microextraction method (MF-LPME) based on applying low density organic solvent was developed for the determination of antifoulings (Irgarol 1051...
Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays.Environ. Sci. Technol. 44(12) , 4775-81, (2010)
Due to the implementation of new legislation, such as REACh, a dramatic increase of animal use for toxicity testing is expected and the search for alternatives is timely. Cell-based in vitro assays ar...
Population growth rate responses of Ceriodaphnia dubia to ternary mixtures of specific acting chemicals: pharmacological versus ecotoxicological modes of action.Environ. Sci. Technol. 46(17) , 9663-72, (2012)
When considering joint toxic apical effects at higher levels of biological organization, such as the growth of populations, the so-called pharmacological mode of action that relies on toxicological me...
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区域：上海市奉贤区
价格：
￥88.0/100g
￥238.0/500g
联系人：刘佳
产品详情：3,4-二氯苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥109.0/1g
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￥需询单/1g
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