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5-磺基水杨酸

5-磺基水杨酸用途

5-磺基水杨酸是一种磺化水杨酸衍生物。5-磺基水杨酸对乳腺癌细胞系MCF-7有效,毒性较低[1]。5-磺基水杨酸具有抗氧化活性[2]。

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5-磺基水杨酸名称

[ CAS 号 ]:
97-05-2

[ 中文名 ]:
5-磺基水杨酸

[ 英文名 ]:
Sulfosalicylic Acid

[中文别名 ]:

[英文别名 ]:

Sulfosalicylic Acid
5-Sulfosalicylic Acid
EINECS 202-555-6
MFCD00007508
Benzoic acid, 2-hydroxy-5-sulfo-
Sulphosalicylic acid
2-Hydroxy-5-sulfobenzoic acid

5-磺基水杨酸生物活性

[ 描述 ]:

5-磺基水杨酸是一种磺化水杨酸衍生物。5-磺基水杨酸对乳腺癌细胞系MCF-7有效,毒性较低[1]。5-磺基水杨酸具有抗氧化活性[2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

5-磺基水杨酸(0.5-4 mM,24小时)显示MCF-7细胞的活力降低[1]。细胞毒性试验[1]细胞系：MCF-7和HUVEC细胞浓度：0.5、1、2、4 mM培养时间：24小时结果：在1 mM 5-磺基水杨酸条件下,MCF-7HUVEC对照细胞的存活率分别为63.3%和70.4%。

[参考文献]

[1]. Münteha Özsoy, et al. A protein-sulfosalicylic acid/boswellic acids @metal-organic framework nanocomposite as anticancer drug delivery system. Colloids Surf B Biointerfaces. 2021 Aug;204:111788.

[2]. K. Ezhilmathi, et al. Effect of 5-sulfosalicylic acid on antioxidant activity in relation to vase life of Gladiolus cut flowers. Plant Growth Regul 51, 99 (2007).

5-磺基水杨酸物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 熔点 ]:
120°C

[ 分子式 ]:
C₇H₆O₆S

[ 分子量 ]:
218.184

[ 精确质量 ]:
217.988510

[ PSA ]:
120.28000

[ LogP ]:
-0.69

[ 外观性状 ]:
白色至灰白色,吸湿的,结晶粉末

[ 折射率 ]:
1.650

[ 储存条件 ]:
室温，干燥

5-磺基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO6500000

CHEMICAL NAME :: Salicylic acid, 5-sulfo-

CAS REGISTRY NUMBER :: 97-05-2

BEILSTEIN REFERENCE NO. :: 0650741

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C7-H6-O6-S

MOLECULAR WEIGHT :: 218.19

WISWESSER LINE NOTATION :: WSQR DQ CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570587

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,565,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7940 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570587 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81215 No. of Facilities: 2580 (estimated) No. of Industries: 7 No. of Occupations: 10 No. of Employees: 18777 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81215 No. of Facilities: 1425 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 44936 (estimated) No. of Female Employees: 36255 (estimated)

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5-磺基水杨酸安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 1760

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2918290000

5-磺基水杨酸合成路线

详细合成路线

5-磺基水杨酸上下游产品

5-磺基水杨酸上游产品

5-磺基水杨酸下游产品

5-磺基水杨酸制备

用水杨酸经磺化制得。

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5-磺基水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

5-磺基水杨酸

5-磺基水杨酸用途

5-磺基水杨酸名称

5-磺基水杨酸生物活性

5-磺基水杨酸物理化学性质

5-磺基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

5-磺基水杨酸安全信息

5-磺基水杨酸合成路线

详细合成路线

5-磺基水杨酸上下游产品

5-磺基水杨酸上游产品

5-磺基水杨酸下游产品

5-磺基水杨酸制备

5-磺基水杨酸海关

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