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戊酸雌二醇

戊酸雌二醇用途

Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

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戊酸雌二醇名称

[ CAS 号 ]:
979-32-8

[ 中文名 ]:
戊酸雌二醇

[ 英文名 ]:
Estradiol valerate

[中文别名 ]:

[英文别名 ]:

Estradiol valerate
Estradiol, 17-valerate
Climaval
Estradiol 17β-valerate
DELESTROGEN
EINECS 213-559-2
17-β-ESTRADIOL 17-VALERATE
Progynon-depot
MFCD00056541
Progynova

戊酸雌二醇生物活性

[ 描述 ]:

Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

[ 靶点 ]

Estrogen Receptor/ERR

[体外研究]

β-雌二醇17-戊酸(EV)是一种合成的雌激素,广泛用于激素替代疗法药物中的其他类固醇激素,并在天然水中检测。 EV是雄性和雌性鱼类中的生殖毒物和雌激素化学物质[1]。

[参考文献]

[1]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

[相关活性小分子]

戊酸雌二醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
486.2±45.0 °C at 760 mmHg

[ 熔点 ]:
144°C

[ 分子式 ]:
C₂₃H₃₂O₃

[ 分子量 ]:
356.498

[ 闪点 ]:
191.1±21.5 °C

[ 精确质量 ]:
356.235138

[ PSA ]:
46.53000

[ LogP ]:
6.62

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：不溶；水溶解度：3.6 mg/l 27 °C；易溶于：乙醇,乙醚,二噁烷；可溶于：甲醇,氯仿

戊酸雌二醇MSDS

详细MSDS(安全技术说明书)

戊酸雌二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG5793000

CHEMICAL NAME :: Estradiol, 17-valerate

CAS REGISTRY NUMBER :: 979-32-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C23-H32-O3

MOLECULAR WEIGHT :: 356.55

WISWESSER LINE NOTATION :: L E5 B666TTT&J E1 FOV5 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 336 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in pituitary weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 65,217,1989 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1003,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 ug/kg/W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- Volume(issue)/page/year: 22/23,359,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 31,587,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 1 mg/kg

SEX/DURATION :: female 12-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: PTLGAX Pathology. (Royal College of Pathologists of Australia, 82 Windmill St., Sydney, NSW, Australia) V.1- 1969- Volume(issue)/page/year: 5,183,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 30,556,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intracerebral

DOSE :: 3200 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25,351,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intracerebral

DOSE :: 3200 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25,351,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 67 ug/kg

SEX/DURATION :: female 15-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: BEMTAM Berliner und Muenchener Tieraerztliche Wochenschrift. (Verlag Paul Parey, Lindenstr. 44-47, D-1000 Berlin 61, Fed. Rep. Ger.) V.54- 1938- Volume(issue)/page/year: 88,385,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 50 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: BEMTAM Berliner und Muenchener Tieraerztliche Wochenschrift. (Verlag Paul Parey, Lindenstr. 44-47, D-1000 Berlin 61, Fed. Rep. Ger.) V.54- 1938- Volume(issue)/page/year: 88,385,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 100 ug/kg

SEX/DURATION :: female 9-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 80,133,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 167 ug/kg

SEX/DURATION :: female 9-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 44,1063,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6242 No. of Facilities: 39 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 911 (estimated) No. of Female Employees: 492 (estimated)

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戊酸雌二醇安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R60;R61

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ RTECS号 ]:
KG5793000

戊酸雌二醇合成路线

详细合成路线

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戊酸雌二醇文献

Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay.

Environ. Toxicol. Pharmacol. 38(3) , 829-37, (2014)

The increasing amounts of various estrogenic chemicals coexisting in the aquatic environment may pose environmental risks. While the concept of estradiol equivalent (EEQ) has been frequently applied i...

Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device.

J. Assist. Reprod. Genet. 32(4) , 521-6, (2015)

Closed vitrification poses a risk of adversely affecting embryo development, while it may minimize the risk of contamination. We assessed the effects of closed-system human embryo vitrification on fet...

Direct analysis in real time - high resolution mass spectrometry (DART-HRMS): a high throughput strategy for identification and quantification of anabolic steroid esters.

Drug Test. Anal. 7 , 603-8, (2015)

High throughput screening is essential for doping, forensic, and food safety laboratories. While hyphenated chromatography-mass spectrometry (MS) remains the approach of choice, recent ambient MS tech...

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