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百日咳毒素

百日咳毒素用途

Pertussis Toxin 是由细菌 Bordetella pertussis 产生的,以蛋白质为基础的 AB5 型外毒素。

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百日咳毒素名称

[ CAS 号 ]:
70323-44-3

[ 中文名 ]:
百日咳毒素(无盐)

[ 英文名 ]:
pertussis toxin

[英文别名 ]:

MFCD00131841

百日咳毒素生物活性

[ 描述 ]:

Pertussis Toxin 是由细菌 Bordetella pertussis 产生的,以蛋白质为基础的 AB5 型外毒素。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 感染

[体外研究]

百日咳毒素是一种分泌的蛋白质外毒素,是由百日咳博德特氏菌专门产生的重要毒力因子。

[参考文献]

[1]. Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5(3):455-69.

[相关活性小分子]

百日咳毒素物理化学性质

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
2-8°C

百日咳毒素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
XW5883750

[ 包装等级 ]:
I

百日咳毒素文献

Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis.

PLoS ONE 3(9) , e3145, (2008)

Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS is cell transplantation which may promote remyelina...

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.

J. Neurosci. 30 , 10282-93, (2010)

Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly. Here, we found that PAP inhi...

Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.

PLoS ONE 7 , e33671, (2012)

An alternative hypothesis has been proposed implicating chronic cerebrospinal venous insufficiency (CCSVI) as a potential cause of multiple sclerosis (MS). We aimed to evaluate the validity of this hy...

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