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肝素锂

肝素锂用途

Heparin Lithium salt 是一种抗凝剂,可与抗凝血酶III (ATIII) 可逆地结合。

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肝素锂名称

[ CAS 号 ]:
9045-22-1

[ 中文名 ]:
肝素锂

[ 英文名 ]:
Heparin lithium salt

[中文别名 ]:

肉桂酸

[英文别名 ]:

(E)-3-Phenylprop-2-enoic acid
Propenoic acid, 3-phenyl-, (trans)-
MFCD00131308
Cinnamic acid
(2E)-3-Phenylacrylic acid
trans-Cinnamic Acid
QV1U1R &&Trans or E Form
2-Propenoic acid, 3-phenyl-, (2E)-
4-09-00-02002 (Beilstein Handbook Reference)
trans-b-Carboxystyrene

肝素锂生物活性

[ 描述 ]:

Heparin Lithium salt 是一种抗凝剂,可与抗凝血酶III (ATIII) 可逆地结合。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 其他

[ 靶点 ]

Antithrombin III[1]

[体外研究]

肝素是一种有效的抗凝血药物,基于其加速抗凝血酶抑制血液凝固级联中丝氨酸蛋白酶的速率的能力。肝素与含有高正电荷密度的互补结合位点的肽最紧密地相互作用。肝素类似于DNA,因为它们都是高电荷的线性聚合物,其表现为聚电解质。肝素被认为主要通过其与AT III的相互作用起抗凝作用,通过增强AT-III介导的凝血因子(包括凝血酶和因子Xa)的抑制。肝素以三元复合物与AT III和凝血酶结合,使凝血酶抑制的双分子速率恒定增加2000倍。肝素主要位于与免疫应答密切相关的组织肥大细胞颗粒中。肝素与FGF-2和FGFR-1的多种接触稳定FGF-FGFR结合。肝素还与邻近的FGF-FGFR复合物的FGFR-1接触,因此似乎促进FGFR二聚化[1]。

[参考文献]

[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.

[相关活性小分子]

肝素锂物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
265.0±0.0 °C at 760 mmHg

[ 分子式 ]:
(C₁₄H₂₅NO₂₀S₃)n_.xLi

[ 分子量 ]:
148.159

[ 闪点 ]:
189.5±9.6 °C

[ 精确质量 ]:
148.052429

[ LogP ]:
2.41

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.616

[ 储存条件 ]:
+15C to +30C

肝素锂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MI0700000

[ 海关编码 ]:
29319090

肝素锂文献

Chromium speciation in human blood samples based on acetyl cysteine by dispersive liquid-liquid biomicroextraction and in-vitro evaluation of acetyl cysteine/cysteine for decreasing of hexavalent chromium concentration.

J. Pharm. Biomed. Anal. 118 , 1-8, (2015)

A rapid and efficient method based on ionic liquid dispersive liquid-liquid biomicroextraction (IL-DLLBME) was used for speciation and preconcentration of Chromium (III, VI) in human blood samples bef...

Prevention of venous thromboembolism in surgical patients by low-dose heparin: prepared by the Council on Thrombosis of the American Heart Association.

Circulation 55(2) , 423-426A, (1977)

Presently available data indicate that low-dose heparin will significantly diminish postoperative deep venous thrombosis and pulmonary embolism in patients over the age of 40 subjected to major electi...

Fractionation of low molecular weight heparin species and their interaction with antithrombin.

J. Biol. Chem. 254(8) , 2902-13, (1979)

Preparations of low molecular weight porcine heparin with an average specific anticoagulant activity of 94 units/mg were fractionated into "active" and "relatively inactive" forms of the mucopolysacch...

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肝素锂

肝素锂用途

肝素锂名称

肝素锂生物活性

肝素锂物理化学性质

肝素锂安全信息

肝素锂文献

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