拉氧头孢

Antimicrob. Agents Chemother. 56(10) , 5157-63, (2012)

New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM-1 has a broad spectrum of activity. Docking of the representatives of the β-lacta...

J. Antimicrob. Chemother. 59(4) , 763-6, (2007)

To compare cefoxitin and/or moxalactam 30 microg disc diffusion (DD) methods to detect methicillin resistance in coagulase-negative staphylococci (CoNS) using both high- and low-density (HD/LD) inoculum techniques.A challenge set of 192 CoNS was tested. DD te...

J. Antimicrob. Chemother. 49(2) , 315-20, (2002)

Viable Escherichia coli cells were entrapped in agar gel layers and incubated in a phosphate-limited glucose medium. Immobilized bacteria displayed enhanced alkaline phosphatase activity and overexpressed the outer membrane protein PhoE as compared with free-...

Am. J. Gastroenterol. 94(6) , 1694-6, (1999)

Early syphilitic hepatitis is uncommon and tends to be overlooked. However, the diagnosis of this disease is important, because appropriate treatment results in rapid resolution of the hepatitis. We report a case of subclinical early syphilitic hepatitis exag...

Biochemistry 40(27) , 7992-9, (2001)

Beta-lactamases hydrolyze beta-lactam antibiotics, including penicillins and cephalosporins; these enzymes are the most widespread resistance mechanism to these drugs and pose a growing threat to public health. beta-Lactams that contain a bulky 6(7)alpha subs...

J. Phys. Chem. B 109(33) , 16153-60, (2005)

The whole reaction of the deacylation of class C beta-lactamase was investigated by performing quantum chemical calculations under physiological conditions. In this study, the X-ray crystallographic structure of the inhibitor moxalactam-bound class C beta-lac...

J. Clin. Microbiol. 45(6) , 2005-8, (2007)

The performance of moxalactam with the BD Phoenix system for the detection of methicillin resistance in coagulase-negative staphylococci was evaluated by use of a collection of 186 strains. Moxalactam was a better drug as an indicator of methicillin resistanc...

J. Pharm. Biomed. Anal. 29(1-2) , 341-6, (2002)

The electrochemical behavior of shiomarin (moxalactam; latamoxef sodium) was investigated at hanging copper/amalgam drop electrode (HCADE) in HCl-KCl solution (pH 1.1). It was found that shiomarin can form complex with Cu(II) and can be adsorbed at the electr...

Protein Sci. 10(6) , 1254-9, (2001)

Penicillin-binding proteins (PBPs) catalyze the final stages of bacterial cell wall biosynthesis. PBPs form stable covalent complexes with beta-lactam antibiotics, leading to PBP inactivation and ultimately cell death. To understand more clearly how PBPs reco...

Chirality 11(4) , 309-15, (1999)

We investigated the mechanism of epimerization (R to S or S to R) of moxalactam in serum of rats, dogs, and humans. The epimerization of moxalactam occurred in the serum of these animals, but not in the serum filtrate. The albumin fraction of human serum puri...