反式-2-苯基环丙胺盐酸盐
反式-2-苯基环丙胺盐酸盐结构式
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常用名 | 反式-2-苯基环丙胺盐酸盐 | 英文名 | Tranylcypromine hydrochloride |
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| CAS号 | 1986-47-6 | 分子量 | 169.651 | |
| 密度 | N/A | 沸点 | 218.3ºC at 760mmHg | |
| 分子式 | C9H12ClN | 熔点 | 162-169ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 90.8ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.
Drug Metab. Dispos. 42(12) , 2023-32, (2014) Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer's disease... |
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Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.
Toxicol. Lett. 230(1) , 28-35, (2014) Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhib... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice.
Behav. Brain Res. 277 , 204-10, (2014) In humans, the ingestion of the combination of two or more serotonin (5-HT)-enhancing drugs but also of a single drug in overdose can induce serious adverse effects, which are characteristics of the serotonin syndrome (SS). In mice, acute administration of di... |
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Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits.
Biology (Basel.) 4 , 298-313, (2015) A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper tran... |
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T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release.
Acta Physiol. (Oxf.) 213(4) , 860-7, (2015) Although activated T lymphocytes express tryptophan hydroxylase 1 and produce 5-HT, the metabolic fate and cellular handling of this 5-HT is unclear. Here, we investigated key proteins in T cells linked to 5-HT metabolism and storage and compare differences i... |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Xenobiotica 44(7) , 615-26, (2014) 1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimal... |