苯并噻唑
苯并噻唑结构式
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常用名 | 苯并噻唑 | 英文名 | Benzo[d]thiazole |
|---|---|---|---|---|
| CAS号 | 95-16-9 | 分子量 | 135.186 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 227.0±9.0 °C at 760 mmHg | |
| 分子式 | C7H5NS | 熔点 | 2 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 96.6±7.6 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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Benzothiazole, benzotriazole, and their derivates in clothing textiles--a potential source of environmental pollutants and human exposure.
Environ. Sci. Pollut. Res. Int. 22(8) , 5842-9, (2015) Textiles play an important role in our daily life, and textile production is one of the oldest industries. In the manufacturing chain from natural and/or synthetic fibers to the final clothing products, the use of many different chemicals is ubiquitous. A lot... |
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Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives.
Bioorg. Med. Chem. Lett. 23(1) , 287-90, (2013) Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg yolk angiogenesis model. A comparative study with pure thalid... |
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Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors.
Bioorg. Med. Chem. Lett. 22(15) , 4998-5002, (2012) A new class of benzoxazole and benzothiazole amide derivatives exhibiting potent CYP3A4 inhibiting properties was identified. Extensive lead optimization was aimed at improving the CYP3A4 inhibitory properties as well as overall ADME profile of these amide de... |
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Design, synthesis, in vitro MAO-B inhibitory evaluation, and computational studies of some 6-nitrobenzothiazole-derived semicarbazones.
ChemMedChem 8(3) , 462-74, (2013) Monoamine oxidase B (MAO-B) is an important drug target for the treatment of neurological disorders. A series of 6-nitrobenzothiazole-derived semicarbazones were designed, synthesized, and evaluated as inhibitors of the rat brain MAO-B isoenzyme. Most of the ... |
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Potent and orally efficacious benzothiazole amides as TRPV1 antagonists.
Bioorg. Med. Chem. Lett. 22(19) , 6205-11, (2012) Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening using recombinant human TRPV1 receptor and structure-activity relationships were explored to pinpoint key pharmacophore interactions. By increasing aqueous solubility, th... |
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A fluorescent benzothiazole probe with efficient two-photon absorption.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 274-6, (2012) In this work, we report the two-photon absorption of 2-[4-(dimethylamino)phenyl]-1,3-benzothiazole-6-carbonitrile (DBC) in DMSO solution pumping at 779 nm with a 10 ns pulse laser-Nd:YAG system. The obtained two-photon absorption cross-section in DBC (407 ± 1... |
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Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits.
Pharmacol. Rep. 64(4) , 834-47, (2012) In this study, benzothiazole-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and pot... |
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Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
Bioorg. Med. Chem. 20(11) , 3480-92, (2012) A series of chalcone-amidobenzothiazole conjugates (9a-k and 10a,b) have been synthesized and evaluated for their anticancer activity. All these compounds exhibited potent activity and the IC(50) of two potential compounds (9a and 9f) against different cancer... |
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Toward prediction of alkane/water partition coefficients.
J. Med. Chem. 51 , 3720-30, (2008) Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literatu... |