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吡噻硫酮

吡噻硫酮结构式
吡噻硫酮结构式
品牌特惠专场
常用名 吡噻硫酮 英文名 Oltipraz
CAS号 64224-21-1 分子量 226.342
密度 1.5±0.1 g/cm3 沸点 408.1±55.0 °C at 760 mmHg
分子式 C8H6N2S3 熔点 165-166ºC
MSDS 中文版 美版 闪点 200.6±31.5 °C
符号 GHS07
GHS07
信号词 Warning

Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.

Diabetes 63(10) , 3483-96, (2014)

This study investigated the impact of catalase (Cat) overexpression in renal proximal tubule cells (RPTCs) on nuclear factor erythroid 2-related factor 2 (Nrf2) stimulation of angiotensinogen (Agt) gene expression and the development of hypertension and renal...

Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.

Expert Opin. Drug Metab. Toxicol. 6(2) , 213-24, (2010)

Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mitochondrial protection and cytoprotective effect against oxi...

Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.

Oncol. Rep. 21(6) , 1559-65, (2009)

Inducers of phase II detoxifying enzymes have been studied as chemopreventive agents for a variety of cancers. Phase II detoxifying enzymes may play a significant role in preventing carcinogen-induced colon cancer at the initiation and post-initiation stage, ...

Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.

Arch. Pharm. Res. 32(4) , 625-35, (2009)

Oltipraz, a representative cancer chemopreventive agent, regenerates cirrhotic liver via CCAAT/enhancer binding protein beta (C/EBPbeta). This study examined the effect of oltipraz on liver regeneration after partial hepatectomy (PH) and explored the role of ...

Pharmacokinetic interaction between oltipraz and silymarin in rats.

J. Pharm. Pharm. Sci. 12(1) , 1-16, (2009)

To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague-Dawley rats.Oltipraz (single doses of 10 and 30 mg/kg for intravenous and oral administration, respectively), si...

This month in APR.

Arch. Pharm. Res. 32(4) , 463-4, (2009)

Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.

Chem. Res. Toxicol. 22(8) , 1427-34, (2009)

The ability of three dithiolethione cancer chemopreventives, oltipraz 1, anetholedithione (ADT) 2, 1,2-dithiole-3-thione (D3T) 3, and the major metabolite, 4, of 1, to induce the cytoprotective enzyme NQO1 in Hepa 1c1c7 cells and the inhibition of this induct...

Therapeutic potential of dithiolethiones for hepatic diseases.

Pharmacol. Ther. 124(1) , 31-43, (2009)

Comprehensive studies support the notion that oltipraz [4-methyl-5-(2-pyrazynyl)-1,2-dithiole-3-thione] and its congeners exert cancer chemopreventive effects by the prevention, inhibition or reversal of carcinogenic processes. Recently, it was found that dit...

Handling the limit of detection by extrapolation.

Stat. Med. 31(26) , 3133-46, (2012)

A general method of estimation with a variable observed subject to a limit of detection is introduced. It is based on extrapolation of the estimates obtained by increasing the limit of detection. Theoretical arguments support the method in some special cases,...

Cancer chemoprotection by oltipraz: experimental and clinical considerations.

Prev. Med. 22(5) , 783-95, (1993)

Oltipraz (4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione) is an antischistosomal drug presently under evaluation as a possible chemoprotective agent in humans. To date, oltipraz has proved effective as an inhibitor of carcinogenesis in experimental models for...