敌菌净结构式
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常用名 | 敌菌净 | 英文名 | Diaveridine |
|---|---|---|---|---|
| CAS号 | 5355-16-8 | 分子量 | 260.292 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 506.1±60.0 °C at 760 mmHg | |
| 分子式 | C13H16N4O2 | 熔点 | 232 - 236ºC | |
| MSDS | 中文版 美版 | 闪点 | 259.9±32.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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[Polarographic determination of diaveridine in biological samples].
Acta Pharm. Hung. 60(1) , 23-9, (1990) Differential pulse polarographic method was applied for determination of diaveridine in plasma, whole blood and isolated organs (liver, spleen, kidney, thymus). Deproteinization of homogenized blood and organs had been carried out on Extrelut column and then ... |
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Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia.
Antimicrob. Agents Chemother. 32(1) , 96-103, (1988) Inhibitors of folic acid synthesis were compared alone and in different combinations in the therapy of pneumocystosis in immunosuppressed rats. Sulfonamides (sulfamethoxazole, sulfadiazine, and sulfadoxine) and sulfones (dapsone) used alone were very active a... |
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Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine.
Am. J. Vet. Res. 57(1) , 68-72, (1996) To examine the efficacies of combinations of 7 sulfonamides and 5 dihydrofolate reductase/thymidylate synthase (DHFR/TS) inhibitors against tachyzoites of Neospora caninum in cultured cells. Mutant tachyzoites that were resistant to pyrimethamine were produce... |
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Determination of residual diaveridine and sulfaquinoxaline in Hen's egg, chicken plasma and tissues by high-performance liquid chromatography.
Chem. Pharm. Bull. 29(8) , 2290-5, (1981)
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Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay.
Mutat. Res. 261(2) , 149-52, (1991) The coccidiostat diaveridine was tested for mutagenicity in the Salmonella/microsome assay with tester strains TA100 and TA98. This compound was not mutagenic in either tester strain in the presence and absence of rat S9 mix, but was found to be mutagenic in ... |
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Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry.
Biomed. Chromatogr. 26(9) , 1101-8, (2012) Trimethoprim (TMP) and diaveridine (DVD) are used in combination with sulfonamides and sulfaquinoxlaine as an effective antibacterial agent and antiprotozoal agent, respectively, in humans and animals. To gain a better understanding of the metabolism of TMP a... |
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Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment.
Environ. Mol. Mutagen. 39(1) , 43-8, (2002) We examined the mutagenic activities of six antiprotozoal drugs (three diaminopyrimidine compounds [pyrimethamine, diaveridine, and trimethoprim] and three 8-aminoquinoline derivatives [primaquine, pentaquine, and pamaquine]) in Escherichia coli WP2uvrA/pKM10... |
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[Effect of sulfaquinoxaline and diaveridine on leucocytozoon infection in chickens].
Nippon. Yakurigaku Zasshi. 86(6) , 411-5, (1985) The preventive effect of sulfaquinoxaline and diaveridine in combination against leucocytozoon infection in White Leghorn female chickens was tested in a field trial. The experiment was initiated when the animals were 120 days old, and it lasted for 10 weeks.... |
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A new antiinflammatory agent (EGIS-5645) without gastrointestinal side-effect.
Agents Actions. Suppl. 32 , 39-43, (1991) The compound EGIS-5645 is a potent antipyretic agent possessing analgesic and antiinflammatory properties. The drug is active in antiinflammatory models such as carrageenin oedema and adjuvant arthritis. EGIS-5645 shows practically no gastro-ulcerogenic effec... |