2-甲基-D-苯丙氨酸
2-甲基-D-苯丙氨酸结构式
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常用名 | 2-甲基-D-苯丙氨酸 | 英文名 | a-methyl-D-phenylalanine |
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| CAS号 | 17350-84-4 | 分子量 | 179.216 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 312.8±30.0 °C at 760 mmHg | |
| 分子式 | C10H13NO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 143.0±24.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Effects of dietary mixtures of amino acids on fetal growth and maternal and fetal amino acid pools in experimental maternal phenylketonuria.
Am. J. Clin. Nutr. 69(4) , 687-96, (1999) Branched-chain amino acids have been reported to improve fetal brain development in a rat model in which maternal phenylketonuria (PKU) is induced by the inclusion of an inhibitor of phenylalanine hydroxylase, DL-p-chlorophenylalanine, and L-phenylalanine in ... |
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Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.
Neurochem. Res. 13(6) , 551-5, (1988) Experimental hyperphenylalaninemia has been induced in 5-day-old chicks by dietary treatments with phenylalanine and alpha-methylphenylalanine. An increase of nearly 8-fold in plasma Phe/Tyr ratio was found after 4 days of supplementation the standard diet wi... |
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Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex.
Neurochem. Res. 19(9) , 1175-80, (1994) The in vitro effects of phenylalanine and some of its metabolites on ATP diphosphohydrolase (apyrase, EC 3.6.1.5) activity in synaptosomes from rat cerebral cortex were investigated. The enzyme activity in synaptosomes from rats subjected to experimental hype... |
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Hyperphenylalaninemia reduces creatine kinase activity in the cerebral cortex of rats.
Int. J. Dev. Neurosci. 21(2) , 111-6, (2003) Phenylketonuria (PKU) is a metabolic disorder accumulating phenylalanine (Phe) and its metabolites in plasma and tissues of the patients. Considering that phenylalanine is the main neurotoxic metabolite, and brain energy homeostasis seems to be affected in ph... |
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Alanine prevents the decrease of Na+,K+-ATPase activity in experimental phenylketonuria.
Metab. Brain Dis. 14(2) , 95-101, (1999) Our objective was to investigate the effect of alanine administration on Na+,K+-ATPase activity in cerebral cortex of rats subjected to chemically-induced phenylketonuria. Wistar rats were treated from the 6th to the 28th day of life with subcutaneous injecti... |
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Effect of phenylalanine and alpha-methylphenylalanine on in vitro incorporation of 32P into cytoskeletal cerebral proteins.
Neurochem. Int. 26(4) , 381-5, (1995) We studied the effects of L-phenylalanine and alpha-methylphenylalanine on 32P in vitro incorporation into cytoskeletal proteins from cerebral cortex of 17-day-old rats. Slices of cerebral cortex were incubated in the absence or presence of increasing concent... |
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Developmental changes of cerebral phenylalanine uptake from severely elevated blood levels.
Neurochem. Res. 9(6) , 837-48, (1984) Brain phenylalanine concentrations at plasma levels raised to that in phenylketonuric subjects were studied in rats from fetal through postnatal life. Suppression of the hepatic phenylalanine hydroxylase with alpha methylphenylalanine, and injections of age-a... |
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Effect of hyperphenylalaninemia induced during suckling on brain DNA metabolism in rat pups.
Neurochem. Res. 9(4) , 517-28, (1984) We studied DNA metabolism (synthesis and degradation) in brain to investigate the effect of hyperphenylalaninemia induced in rats by treatment with PCPA or alpha MPA plus PHE during suckling (4th-20th days of postnatal age) on cell proliferation and naturally... |
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Effect of experimental hyperphenylalaninemia induced by dietary phenylalanine plus alpha-methylphenylalanine administration on amino acid concentration in neonatal chick brain, plasma, and liver.
Neurochem. Res. 13(6) , 547-50, (1988) Supplementation of 5% phenylalanine plus 0.4% alpha-methylphenylalanine to the standard diet or 1% phenylalanine plus 0.08% alpha-methylphenylalanine to the drinking water produced phenylketonuria-like conditions in 5-day-old chicks. An increase of 10 to 15-f... |
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Effect of phenylalanine, p-chlorophenylalanine and alpha-methylphenylalanine on glucose uptake in vitro by the brain of young rats.
Biochem. Soc. Trans. 18(3) , 419, (1990)
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