姜黄素
姜黄素结构式
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常用名 | 姜黄素 | 英文名 | Curcumin |
|---|---|---|---|---|
| CAS号 | 458-37-7 | 分子量 | 368.380 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 593.2±50.0 °C at 760 mmHg | |
| 分子式 | C21H20O6 | 熔点 | 183 °C | |
| MSDS | 中文版 美版 | 闪点 | 209.7±23.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Mucoadhesive films containing chitosan-coated nanoparticles: a new strategy for buccal curcumin release.
J. Pharm. Sci. 103(11) , 3764-71, (2014) Mucoadhesive films containing curcumin-loaded nanoparticles were developed, aiming to prolong the residence time of the dosage form in the oral cavity and to increase drug absorption through the buccal mucosa. Films were prepared by the casting method after i... |
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Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site.
Org. Biomol. Chem. 13(10) , 3040-7, (2015) Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones... |
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An antifungal mechanism of curcumin lies in membrane-targeted action within Candida albicans.
IUBMB Life 66(11) , 780-5, (2015) The aim of this study is to investigate the antifungal mechanism of curcumin. This polyphenolic compound has been used traditionally in Asia for medicinal, culinary, and other purposes. Although antifungal effect of curcumin has been reported, this is the fir... |
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Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 (FZD4) missense mutants associated with familial exudative vitreoretinopathy.
Invest. Ophthalmol. Vis. Sci. 55(6) , 3423-31, (2014) Fifteen missense mutations in the frizzled family receptor 4 (FZD4) reported to cause familial exudative vitreoretinopathy (FEVR) were evaluated to establish the pathological cellular mechanism of disease and to explore novel therapeutic strategies.The mutati... |
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Improved plasma membrane expression of the trafficking defective P344R mutant of muscle, skeletal, receptor tyrosine kinase (MuSK) causing congenital myasthenic syndrome.
Int. J. Biochem. Cell Biol. 60 , 119-29, (2015) Muscle, skeletal, receptor tyrosine kinase (MuSK) is a key organizer at the postsynaptic membrane and critical for proper development and maintenance of the neuromuscular junction. Mutations in MUSK result in congenital myasthenic syndrome (CMS). We hypothesi... |
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Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.
J. Cell. Biochem. 116 , 1553-62, (2015) Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections.... |
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Evolution of availability of curcumin inside poly-lactic-co-glycolic acid nanoparticles: impact on antioxidant and antinitrosant properties.
Int. J. Nanomedicine 10 , 5355-66, (2015) Curcumin exhibits antioxidant properties potentially beneficial for human health; however, its use in clinical applications is limited by its poor solubility and relative instability. Nanoparticles exhibit interesting features for the efficient distribution a... |
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Curcumin delivery from poly(acrylic acid-co-methyl methacrylate) hollow microparticles prevents dopamine-induced toxicity in rat brain synaptosomes.
Int. J. Pharm. 486 , 259-67, (2015) The potential of poly(methyl methacrylate-co-acrylic acid) (PMMA-AA) copolymers to form hollow particles and their further formulation as curcumin delivery system have been explored. The particles were functionalized by crosslinking the acrylic acid groups vi... |
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Expression and function of connexin 43 in human gingival wound healing and fibroblasts.
PLoS ONE 10(1) , e0115524, (2015) Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among... |
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Remarkable enhancement in photocytotoxicity and hydrolytic stability of curcumin on binding to an oxovanadium(IV) moiety.
Dalton Trans. 44(9) , 4108-22, (2015) Oxovanadium(IV) complexes of polypyridyl and curcumin-based ligands, viz. [VO(cur)(L)Cl] (1, 2) and [VO(scur)(L)Cl] (3, 4), where L is 1,10-phenanthroline (phen in 1 and 3), dipyrido[3,2-a:2',3'-c]phenazine (dppz in 2 and 4), Hcur is curcumin and Hscur is dig... |