三氯乙腈结构式
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常用名 | 三氯乙腈 | 英文名 | Trichloroacetonitrile |
|---|---|---|---|---|
| CAS号 | 545-06-2 | 分子量 | 144.387 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 85.7±0.0 °C at 760 mmHg | |
| 分子式 | C2Cl3N | 熔点 | -42 °C | |
| MSDS | 中文版 美版 | 闪点 | 10.5±20.2 °C | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Identification of two urinary metabolites of rats treated with acrylonitrile; influence of several inhibitors on the mutagenicity of those urines.
Toxicol. Lett. 7(4-5) , 321-7, (1981) Urines collected from rats injected with acrylonitrile (ACN) were mutagenic towards Salmonella typhimurium TA1530; this activity was reduced when the animals were pretreated by pyrazole (inhibitor of alcohol dehydrogenase) and suppressed after pretreatment ei... |
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Trichloroacetonitrile.
IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1533-7, (1999)
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Teratogenic effects of trichloroacetonitrile in the Long-Evans rat.
Teratology 38(2) , 113-20, (1988) Trichloroacetonitrile (TCAN) is among a number of contaminants found in drinking water produced by reactions of chlorine with background organic material. Long-Evans rats were intubated with TCAN (0, 1, 7.5, 15, 35, 55 mg/kg) in a tricaprylin vehicle on gesta... |
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Genotoxic activity of five haloacetonitriles: comparative investigations in the single cell gel electrophoresis (comet) assay and the ames-fluctuation test.
Environ. Mol. Mutagen. 36(1) , 52-8, (2000) Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to... |
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Characterization of dissolved organic matter fractions and its relationship with the disinfection by-product formation.
J. Environ. Sci. (China) 21(1) , 54-61, (2009) Dissolved organic matter (DOM) has been identified as precursor for disinfection by-products (DBPs) formation during chlorination. Recently, it has been demonstrated that the characteristics of DOM influence the DBPs formation mechanism. A study was, therefor... |
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Developmental effects of trichloroacetonitrile administered in corn oil to pregnant Long-Evans rats.
J. Toxicol. Environ. Health A 47(3) , 233-47, (1996) Trichloroacetonitrile (TCAN) is a by-product of the chlorine disinfection of water containing natural organic material. When administered by gavage to pregnant Long-Evans rats in a medium-chain triglyceride vehicle, tricaprylin oil (Tricap), at a volume of 10... |
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Regio- and stereoselective anomeric esterification of glucopyranose 1,2-diols and a facile preparation of 2-O-acetylated glucopyranosyl trichloroacetimidates from the corresponding 1,2-diols.
Carbohydr. Res. 342(6) , 797-805, (2007) A highly regio- and stereoselective anomeric esterification of 3-O-allyl (or benzyl, or benzoyl)-4,6-O-isopropylidene-alpha,beta-d-glucopyranose with acetyl chloride, or allyl chloroformate, or ethyl chloroformate gave the corresponding 2-OH, 1-beta-acetates ... |
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Macromolecular adduction by trichloroacetonitrile in the Fischer 344 rat following oral gavage.
Cancer Lett. 62(1) , 1-9, (1992) Male Fisher 344 rats were administered 1- or 2-[14C]trichloroacetonitrile (TCAN) by oral gavage. DNA was isolated from the liver, kidneys and stomach and several protein fractions (globin, albumin and globulins) were isolated from blood. TCAN binds to both th... |
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Synthesis of protected chiral vicinal diaminoalcohols by diastereoselective intramolecular benzylic substitution from bistrichloroacetimidates.
Org. Lett. 9 , 247, (2007) An efficient synthesis of chiral dihydrooxazines (2) from 1-aryl-2-amino-propane-1,3-diols (1) via the corresponding bistrichloroacetimidate intermediates has been developed. In this transformation, one trichloroacetimidate acts as a leaving group and the oth... |
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Tetrahedron 63 , 2123, (2007)
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