(-)-α-Acetylmethadol Hydrochloride
(-)-α-Acetylmethadol Hydrochloride结构式
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常用名 | (-)-α-Acetylmethadol Hydrochloride | 英文名 | (-)-α-Acetylmethadol Hydrochloride |
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| CAS号 | 43033-72-3 | 分子量 | 389.95900 | |
| 密度 | N/A | 沸点 | 456ºC at 760 mmHg | |
| 分子式 | C23H32ClNO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 130ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Opioids, QTc prolongation, and torsades.
J. Clin. Pharmacol. 52(10) , 1614, (2012)
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Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis.
Am. J. Addict. 19(2) , 169-77, (2010) This randomized clinical trial retrospectively examined the effect of post-traumatic stress disorder (PTSD) and contingency management (CM) on cocaine use in opioid and cocaine dependent individuals maintained on high or low-dose LAAM randomly assigned to CM ... |
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Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: a retrospective analysis.
Pharmacol. Biochem. Behav. 90(4) , 787-96, (2008) Pooled self-report and physiological data from 32 male and 15 female methadone or levo-alpha-acetyl methadol (LAAM) maintained volunteers were retrospectively analyzed for individual differences in response to naloxone (0.15 mg/70 kg, IM) and placebo at 20 an... |
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A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction.
Pharmacopsychiatry 42(1) , 1-8, (2009) Levo-Alpha-Acetylmethadol (LAAM) is a synthetic opioid analgesic with mu-agonistic activity and a long duration of action. There are several, almost exclusively US American studies showing the efficacy of LAAM as a maintenance drug which has the advantage tha... |
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Prenatal opiate exposure attenuates LPS-induced fever in adult rats: role of interleukin-1beta.
Brain Res. 1133(1) , 92-9, (2007) Much is known about the immunomodulatory effects of opiate exposure and withdrawal in adult rats. However, little research has delved into understanding the immunological consequences of prenatal opiate exposure and postnatal withdrawal. The purpose of the cu... |
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Longitudinal effects of LAAM and methadone maintenance on heroin addict behavior.
J. Behav. Health Serv. Res. 36(2) , 267-82, (2009) Levo-alpha-acetylmethadol maintenance (LAAM) was compared to methadone maintenance (MM) on the behavioral performance of 315 heroin addicts before, during, and after 12 months of fully subsidized treatment. Assessments of drug use, criminal behavior, HIV risk... |
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Levo-alpha-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial.
Eur. J. Med. Res. 14(1) , 7-12, (2009) Due to potential proarrhythmic side-effects levo-alpha-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LA... |
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No opiate substitutes for the masses of IDUs.
Science 329(5988) , 165-7, (2010)
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Levomethadone is poorly removed by the molecular adsorbents recirculating system.
J. Clin. Psychopharmacol. 29(6) , 622-4, (2009)
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Can LAAM, like Lazarus, come back from the dead?
Addiction 102(9) , 1342-3, (2007)
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