2,3-二氯-1,4-萘醌
一般危化品
2,3-二氯-1,4-萘醌结构式
|
常用名 | 2,3-二氯-1,4-萘醌 | 英文名 | 2,3-Dichlor-1,4-naphthochinone |
|---|---|---|---|---|
| CAS号 | 117-80-6 | 分子量 | 227.044 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 304.0±42.0 °C at 760 mmHg | |
| 分子式 | C10H4Cl2O2 | 熔点 | 194-197 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 127.5±28.5 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
|
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
J. Med. Chem. 51 , 1706-18, (2008) Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. While small molecule inhibitors of IDO exist, ther... |
|
|
The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.
Bioorg. Med. Chem. 15 , 5340-50, (2007) A series of 1,4-naphthoquinone derivatives diversely substituted at C-2, C-3, C-5 and C-8, prepared by reaction of amines, amino acids and alcohols with commercial 1,4-naphthoquinones, has been evaluated against papain and bovine spleen cathepsin B. These 1,4... |
|
|
Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone).
Bull. Environ. Contam. Toxicol. 41(2) , 164-71, (1988)
|
|
|
Spectroscopic and theoretical studies on the nucleophilic substitution of 2,3-dichloronaphthoquinone with para-substituted anilines in solid state via initial charge transfer complexation.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 98 , 378-83, (2012) Various spectroscopy techniques (UV-Vis, DRS, FT-IR, (1)H NMR, LC-MS) and theoretical computations have been employed to investigate the mechanism of the nucleophilic substitution reaction of 2,3-dichloronaphthoquinone (DCNQ) with para-substituted anilines in... |
|
|
Study of a reaction between 2,3-dichloro-1,4-naphthoquinone and N,N'-diphenyl thiourea involving an EDA adduct as intermediate.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 60(7) , 1641-7, (2004) The reaction between 2,3-dichloro-1,4-naphthoquinone and N,N'-diphenyl thiourea in acetonitrile medium, which yields the product, 2,3-(N,N'-diphenylthioureylene)-naphtho-1,4-quinone has been found to take place in two ways--thermal and photochemical. The ther... |
|
|
Charge transfer interaction of 4-acetamidophenol (paracetamol) with 2,3-dichloro-1,4-naphthoquinone: a study in aqueous ethanol medium by UV-vis spectroscopic and DFT methods.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 71(3) , 835-40, (2008) 4-Acetamidophenol (paracetamol) is shown to form charge transfer complex with 2,3-dichloro1,4-naphthoquinone in aqueous ethanol media exhibiting the unusual 2:1 (paracetamol:quinone) stoichiometry. The complexation enthalpy and entropy have been estimated fro... |
|
|
Dichlone-induced oxidative stress in a model insect species, Spodoptera eridania.
Arch. Environ. Contam. Toxicol. 29(4) , 442-8, (1995) Southern armyworm, Spodoptera eridania, larvae were provided ad libitum 0.002-0.25% w/w dichlone, 2,3-dichloro-1,4-naphthoquinone (CNQ). Larval mortality occurred in a time-and-dose dependent manner, with an LC17 of 0.01% and an LC50 of 0.26% CNQ at day-5. Ex... |
|
|
Inhibition of liver glycolysis in rats by dietary dichlone (2,3-dichloro-1,4-naphthoquinone).
Bull. Environ. Contam. Toxicol. 35(1) , 23-8, (1985)
|
|
|
Bacterial growth response to photoactive quinones.
Photochem. Photobiol. 86(6) , 1327-33, (2010) Quinones are known producers of reactive oxygen species (ROS) that may be toxic in natural aquatic environments. In this study, the effects of parent quinones and their photodegradation products on bacterial growth were determined, and photochemical ROS forma... |
|
|
[Reactions between dialkylamine drugs, 2,3-dichloro-1,4-naphthoquinone and acetaldehyde].
Pharmazie 57(8) , 530-4, (2002) Dialkylamine drugs desipramine, propanolol, pindolol, alprenolol and metoprolol 4a-e react with 2,3-dichloro-1,4-naphthoquinone (2) and acetaldehyde to give red coloured 2-dialkylamino-3-chloro-1,4-naphthoquinones 5a, b, d, e, blue coloured 2-dialkylamino-vin... |