L-谷氨酰胺
L-谷氨酰胺结构式
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常用名 | L-谷氨酰胺 | 英文名 | L-Glutamine |
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| CAS号 | 56-85-9 | 分子量 | 146.145 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 353.5±52.0 °C at 760 mmHg | |
| 分子式 | C5H10N2O3 | 熔点 | 185ºC | |
| MSDS | 中文版 美版 | 闪点 | 167.6±30.7 °C |
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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Nat. Commun. 6 , 5794, (2015) Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesio... |
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Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
Biomaterials 51 , 1-11, (2015) Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we rep... |
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25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J. Ethnopharmacol. 164 , 265-72, (2015) Quisqualis indica is used in traditional Chinese medicine to treat cancer and related syndromes and also known for its anthelminthic effects.Soft tissue sarcomas represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance an... |
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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.
Drug Des. Devel. Ther. 9 , 1555-84, (2015) Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays a... |
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SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
Dev. Dyn. 244(4) , 591-606, (2015) Pluripotency, self-renewal, and differentiation are special features of embryonic stem (ES) cells, thereby providing valuable perspectives in regenerative medicine. Developmental processes require a fine-tuned organization, mainly regulated by the well-known ... |
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DNase II-dependent DNA digestion is required for DNA sensing by TLR9.
Nat. Commun. 6 , 5853, (2015) DNase II digests DNA in endolysosomes. In the absence of DNase II, undigested DNA activates cytoplasmic DNA-sensing pathways. Little is known, however, about the role of DNase II in endolysosomal DNA sensing by TLR9. Here we show that DNase II is required for... |
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A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function.
J. Neurosci. 35(5) , 1999-2014, (2015) Approximately one-third of known deafness genes encode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used mass spectrometry to characterize the hair bundle's proteome, resulting in the discove... |
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Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo.
Biochem. Pharmacol. 92(3) , 467-75, (2014) Hepcidin is a peptide hormone that controls systemic iron availability and is upregulated by iron and inflammation. Heparins have been shown to be efficient hepcidin inhibitors both in vitro and in vivo, even when their anticoagulant activity has been abolish... |
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Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors.
Stem Cells 33(1) , 101-10, (2014) Despite advances in standard therapies, the survival of glioblastoma multiforme (GBM) patients has not improved. Limitations to successful translation of new therapies include poor delivery of systemic therapies and use of simplified preclinical models which ... |
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Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Hum. Mol. Genet. 24(1) , 100-17, (2014) The physiological function of Ataxin-3 (ATXN3), a deubiquitylase (DUB) involved in Machado-Joseph Disease (MJD), remains elusive. In this study, we demonstrate that ATXN3 is required for neuronal differentiation and for normal cell morphology, cytoskeletal or... |