L-Glutamine
L-Glutamine structure
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Common Name | L-Glutamine | ||
|---|---|---|---|---|
| CAS Number | 56-85-9 | Molecular Weight | 146.145 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 353.5±52.0 °C at 760 mmHg | |
| Molecular Formula | C5H10N2O3 | Melting Point | 185ºC | |
| MSDS | Chinese USA | Flash Point | 167.6±30.7 °C | |
Use of L-GlutamineL-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.Target: mGluRGlutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders. Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500-900 μmol/L. Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut. The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid-base balance, activated immune cells, and manycancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | L-glutamine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.Target: mGluRGlutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders. Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500-900 μmol/L. Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut. The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid-base balance, activated immune cells, and manycancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 353.5±52.0 °C at 760 mmHg |
| Melting Point | 185ºC |
| Molecular Formula | C5H10N2O3 |
| Molecular Weight | 146.145 |
| Flash Point | 167.6±30.7 °C |
| Exact Mass | 146.069138 |
| PSA | 106.41000 |
| LogP | -1.28 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.564 |
| InChIKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| SMILES | NC(=O)CCC(N)C(=O)O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | MA2275100 |
| HS Code | 2932999099 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 10 | |
CAS#:71989-20-3
CAS#:56-86-0
CAS#:60-24-2
CAS#:30924-93-7
CAS#:2490-97-3
CAS#:1101-67-3
CAS#:50-35-1
CAS#:149-87-1
CAS#:328-50-7
CAS#:18465-19-5
CAS#:39537-23-0
CAS#:3081-61-6
CAS#:945623-40-5
CAS#:3343-29-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Nat. Commun. 6 , 5794, (2015) Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-bin... |
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Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
Biomaterials 51 , 1-11, (2015) Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer c... |
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25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.
J. Ethnopharmacol. 164 , 265-72, (2015) Quisqualis indica is used in traditional Chinese medicine to treat cancer and related syndromes and also known for its anthelminthic effects.Soft tissue sarcomas represent a rare group of malignant tu... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| UNII-U5JDO2770Z |
| EINECS 200-292-1 |
| (2S)-2-((2S)-2-Aminopropanoylamino)-4-carbamoylbutanoic acid |
| ZY1&VMYVQ2VZ &&L-L Form |
| glutaminic acid |
| Gln |
| L-Ala-L-Gln |
| glutamine |
| L-Gln |
| L-Alanyl-L-glutamine |
| Levoglutamide |
| (S)-5-Amino-2-[(S)-2-aminopropanamido]-5-oxopentanoic acid |
| L-Glutamine,L-alanyl |
| (2S)-2-amino-4-carbamoylbutanoic acid |
| Alanyl-glutamine,Glutamine-S |
| MFCD00008044 |
| Ala-Gln |
| L-(+)-Glutamine |
| (S)-(+)-Glutamine |
| 5-Hydroxy-5-imino-L-norvaline |
| N(2)-L-alanyl-L-glutamine |
| Glutamine-S |
| Alanyl-glutamine |
| L-Glutamic Acid g-Amide |
| L-Glutamic acid γ-amide |
| N-L-alanyl-L-glutamine |
| L-Glutamine |
| l-alanyl-l-glutamin |
| l-(+)-glutamic acid-5-amide |
| L-Glutamic acid 5-amide |
| H-Ala-Gln-OH |
| (2S)-5-Amino-2-{[(2S)-2-aminopropanoyl]amino}-5-oxopentanoic acid |
| S(+)-Glutamic acid 5-amide |
| H-Gln-OH |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of L-glutamine? |
| A: CAS number of L-glutamine is 56-85-9. |
| Q: What is the polar surface area (PSA) of L-glutamine? |
| A: Polar surface area (PSA) of L-glutamine is 106.41000. |
| Q: What are the downstream products of L-glutamine? |
| A: Related downstream products(CAS) of L-glutamine: 1101-67-3;50-35-1;149-87-1;328-50-7;18465-19-5;39537-23-0;3081-61-6;56-86-0;945623-40-5;3343-29-1. |
| Q: What is the English name of L-glutamine? |
| A: The English name of L-glutamine is L-glutamine. |
| Q: What is the melting point of L-glutamine? |
| A: Melting point of L-glutamine is 185ºC. |
| Q: What is the molecular weight of L-glutamine? |
| A: Molecular weight of L-glutamine is 146.145. |
| Q: What is the InChIKey of L-glutamine? |
| A: InChIKey of L-glutamine is ZDXPYRJPNDTMRX-VKHMYHEASA-N. |
| Q: What is the LogP of L-glutamine? |
| A: LogP of L-glutamine is -1.28. |
| Q: What are the upstream materials of L-glutamine? |
| A: Related upstream materials(CAS) of L-glutamine: 71989-20-3;56-86-0;60-24-2;30924-93-7;2490-97-3;56-85-9. |
| Q: What is the boiling point of L-glutamine? |
| A: Boiling point of L-glutamine is 353.5±52.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |