希伯胺结构式
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常用名 | 希伯胺 | 英文名 | Xipamide |
|---|---|---|---|---|
| CAS号 | 14293-44-8 | 分子量 | 354.809 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C15H15ClN2O4S | 熔点 | 255-256ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Clinicopharmacological reappraisal of the potency of diuretics.
Cardiovasc. Drugs Ther. 7 Suppl 1 , 23-8, (1993) From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively on the basis of the changes in 24-hour natriuresis, with respect to 24-hour natriuresis after placebo, caused by single oral doses administer... |
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Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination.
J. Pharm. Biomed. Anal. 61 , 78-85, (2012) An efficient chromatographic method for the simultaneous determination of triamterene (TRI) and xipamide (XIP) in urine samples, based on high performance liquid chromatography with photodiode array detector (HPLC-DAD) has been developed. The HPLC separation ... |
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Spectrophotometric and spectrodensitometric determination of triamterene and xipamide in pure form and in pharmaceutical formulation.
Drug Test. Anal. 2(3) , 113-21, (2010) Sensitive and validated UV-spectrophotometric, chemometric and TLC-densitometric methods were developed for determination of triamterene (TRM) and xipamide (XIP) in their binary mixture, formulated for use as a diuretic, without previous separation. Method A ... |
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Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide.
Cardiology 84 Suppl 2 , 87-98, (1994) In a prospective randomized short-term study, the efficacy and safety of xipamide and a combination of spironolactone and furosemide were compared in the treatment of hepatic cirrhotic ascites. Twenty-two patients were randomized to either xipamide, 20 mg/day... |
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Selective and sensitive spectrophotometric method for the determination of trace amounts of zirconium in environmental and biological samples using 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 284-9, (2012) A simple, selective and sensitive spectrophotometric method for the determination of trace amounts of Zr(IV) in aqueous samples was performed, based on complexation reaction between Zr(IV) and 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide (xi... |
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Can xipamide or tacrolimus inhibit the glucuronidation of mycophenolic acid in rat liver slices?
Exp. Toxicol. Pathol. 54(5-6) , 375-9, (2003) The objective of this study was to investigate the effect of tacrolimus (Tac) and xipamide (X) on mycophenolic acid (MPA) glucuronidation in precision-cut rat liver slices. To assess a possible effect of these two drugs, the influence of the anti-inflammatory... |
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Experimental design optimization of a capillary zone electrophoresis method for the screening of several diuretics and ACE inhibitors.
J. Chromatogr. Sci. 42(2) , 74-9, (2004) Experimental design methodologies are applied to the development of a capillary zone electrophoretic method for the separation of the angiotensin-converting enzyme inhibitor enalapril and its derivative enalaprilat and the diuretics xipamide and hydrochloroth... |
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[Mechanism of action of xipamide and its classification as a "low ceiling diuretic". Pharmacodynamic-pharmacokinetic studies in healthy volunteers and in kidney and liver patients].
Arzneimittelforschung 55(1) , 1-14, (2005) Xipamide (CAS 14293-44-8) shows structural features comparable with the thiazide- as well as the class of loop diuretics. According to earlier findings this diuretic, in contrast to the thiazides, should not decrease the glomerular filtration rate (GFR) and b... |
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Low-dose thiazide diuretics in primary hypertension.
S. Afr. Med. J. 81(8) , 437, (1992)
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Determination of Xipamide metabolite in human urine by high-performance liquid chromatography/diode-array detection, high-performance liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry.
Rapid Commun. Mass Spectrom. 18(20) , 2505-12, (2004)
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