4-甲基-2-氧戊酸
4-甲基-2-氧戊酸结构式
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常用名 | 4-甲基-2-氧戊酸 | 英文名 | Ketoleucine |
|---|---|---|---|---|
| CAS号 | 816-66-0 | 分子量 | 130.142 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 190.5±9.0 °C at 760 mmHg | |
| 分子式 | C6H10O3 | 熔点 | 8-10 °C | |
| MSDS | 中文版 美版 | 闪点 | 83.3±15.2 °C | |
| 符号 |
GHS05 |
信号词 | Danger |
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Physiology and pathophysiology of organic acids in cerebrospinal fluid.
J. Inherit. Metab. Dis. 16(4) , 648-69, (1993) Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarboxylic acids from the brain is a major route for removing th... |
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The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.
Biochem. Pharmacol. 80(1) , 104-12, (2010) The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective sulfonylurea concentration (2.7 microM glipizide) the nutri... |
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Production of α-ketoisocaproate via free-whole-cell biotransformation byRhodococcus opacusDSM 43250 withl-leucine as the substrate
Enzyme Microb. Technol. 49(4) , 321-5, (2011) This work aims to produce α-ketoisocaproate (KIC) from l-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cell concentration, and rotating speed on KIC production were ... |
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Atomic-resolution structure of an N5 flavin adduct in D-arginine dehydrogenase.
Biochemistry 50(29) , 6292-4, (2011) D-Arginine dehydrogenase (DADH) catalyzes the flavin-dependent oxidative deamination of D-arginine and other D-amino acids to the corresponding imino acids. The 1.07 Å atomic-resolution structure of DADH crystallized with D-leucine unexpectedly revealed a cov... |
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Nitric oxide (NO)--production and regulation of insulin secretion in islets of freely fed and fasted mice.
Regul. Pept. 174(1-3) , 32-7, (2012) Production of nitric oxide through the action of nitric oxide synthase (NOS) has been detected in the islets of Langerhans. The inducible isoform of NOS (iNOS) is induced by cytokines and might contribute to the development of type-1 diabetes, while the const... |
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Effects of ergot alkaloids on liver function of piglets as evaluated by the (13)C-methacetin and (13)C-α-ketoisocaproic acid breath test.
Toxins (Basel.) 5(1) , 139-61, (2013) Ergot alkaloids (the sum of individual ergot alkaloids are termed as total alkaloids, TA) are produced by the fungus Claviceps purpurea, which infests cereal grains commonly used as feedstuffs. Ergot alkaloids potentially modulate microsomal and mitochondrial... |
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Alterations of urinary metabolite profile in model diabetic nephropathy.
Biochem. Biophys. Res. Commun. 456(2) , 610-4, (2015) Countering the diabetes pandemic and consequent complications, such as nephropathy, will require better understanding of disease mechanisms and development of new diagnostic methods. Animal models can be versatile tools in studies of diabetic renal disease wh... |
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A chiral ligand exchange CE essay with zinc(II)–l-valine complex for determining enzyme kinetic constant ofl-amino acid oxidase
Talanta 81(4-5) , 1554-9, (2010) A new strategy for the enantioseparation of d, l-amino acids employing the principle of ligand exchange capillary electrophoresis with Zn(II)– l-valine complex as a chiral selecting system in the presence of β-cyclodextrin has been designed. Successful enanti... |
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A to Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 21.
Br. J. Sports Med. 45(8) , 677-9, (2011)
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Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.
Biochim. Biophys. Acta 1639(3) , 232-8, (2003) Neurological dysfunction is a common finding in patients with maple syrup urine disease (MSUD). However, the mechanisms underlying the neuropathology of brain damage in this disorder are poorly known. In the present study, we investigated the effect of the in... |