托卡朋
托卡朋结构式
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常用名 | 托卡朋 | 英文名 | Tolcapone |
|---|---|---|---|---|
| CAS号 | 134308-13-7 | 分子量 | 273.241 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 485.6±45.0 °C at 760 mmHg | |
| 分子式 | C14H11NO5 | 熔点 | 126-128ºC | |
| MSDS | 中文版 美版 | 闪点 | 205.7±17.2 °C | |
| 符号 |
GHS09 |
信号词 | Warning |
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Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.
Toxicol. Lett. 214(2) , 175-81, (2012) A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of h... |
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Telescoping phenomenon in pathological gambling: association with gender and comorbidities.
J. Nerv. Ment. Dis. 200(11) , 996-8, (2012) The course of pathological gambling (PG) in women has been described as having a later age of initiation but a shorter time to problematic gambling ("telescoped"). This study examined evidence for telescoping and its relationship with comorbidities. Seventy-o... |
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Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs.
Toxicol. Sci. 113(1) , 243-53, (2010) Capture compound mass spectrometry (CCMS) is a novel technology that helps understand the molecular mechanism of the mode of action of small molecules. The Capture Compounds are trifunctional probes: A selectivity function (the drug) interacts with the protei... |
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Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Behav. Brain Res. 228(2) , 351-8, (2012) Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates... |
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Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.
J. Biol. Chem. 286(40) , 34752-60, (2011) Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. It plays an important role in cognition, arousal, pain sensitivity, and stress reactivity in humans ... |
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Tolcapone: a review of its use in the management of Parkinson's disease.
CNS Drugs 19(2) , 165-84, (2005) Tolcapone (Tasmar) is a selective, reversible inhibitor of peripheral and central catechol-O-methyltransferase (COMT). Results of well designed studies indicate that oral tolcapone is an effective adjunct to levodopa plus a peripheral dopa-decarboxylase inhib... |
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A systematic review of catechol-0-methyltransferase inhibitors: efficacy and safety in clinical practice.
Clin. Neuropharmacol. 35(4) , 185-90, (2012) Catechol-O-methyltransferase (COMT) inhibitors are drugs commonly used in the management of patients with Parkinson disease complicated by motor fluctuations. Among them, entacapone is the most commonly used. Tolcapone has been reintroduced in patients where ... |
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Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease.
CNS Neurosci. Ther. 14(1) , 83-93, (2008) The relative efficacy has not been adequately established for the two catechol-O-methyltransferase (COMT) inhibitors that are currently available for adjunctive therapy in Parkinson's disease; tolcapone and entacapone. A recent Cochrane meta-analysis of 14 st... |
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Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(24) , 2557-65, (2009) The process of drug metabolite identification is extremely important for drug efficacy, safety and pharmacokinetics. The traditional method usually involves using a drug with a radioactive labeled nuclei and/or isolating major drug metabolites by HPLC before ... |
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Tolcapone-related liver dysfunction: implications for use in Parkinson's disease therapy.
Drug Saf. 26(11) , 743-7, (2003) Levodopa is the cornerstone of idiopathic Parkinson's disease (PD) treatment. However, after long-term use of levodopa, a significant percentage of patients experience motor fluctuations, which worsen their quality of life. Catechol-O-methyltransferase (COMT)... |