福莫司汀结构式
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常用名 | 福莫司汀 | 英文名 | Fotemustine |
|---|---|---|---|---|
| CAS号 | 92118-27-9 | 分子量 | 315.691 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 188 °C(lit.) | |
| 分子式 | C9H19ClN3O5P | 熔点 | 85ºC | |
| MSDS | 中文版 美版 | 闪点 | 104 °F | |
| 符号 |
GHS08 |
信号词 | Warning |
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Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature.
Tumori 99(5) , e237-40, (2013) Extracranial metastases from glioblastoma multiforme (GBM) are a very rare event, even if an increasing incidence has been documented. We report the case of a young woman with primary GBM who developed bone metastases without local brain relapse. Because of p... |
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Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma.
J. Transl. Med. 11 , 38, (2013) The effect of the addition of fotemustine and/or interferon (IFN) to standard therapy with dacarbazine alone in patients with advanced malignant melanoma was investigated in a multicenter, randomized 2x2 factorial design trial.A total of 260 patients were ran... |
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Good clinical activity and favorable toxicity profile of once weekly bortezomib, fotemustine, and dexamethasone (B-MuD) for the treatment of relapsed multiple myeloma.
Am. J. Hematol. 88(2) , 102-6, (2013) Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new three drug combination in which Fotemustine (Muphoran), an alky... |
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High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.
J. Transl. Med. 8 , 115, (2010)
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Fotemustine in the treatment of brain primary tumors and metastases.
Cancer Invest. 12(4) , 414-20, (1994) Fotemustine is a new chloroethylnitrosourea characterized by the grafting of a phosphonoalanine group onto a nitrosourea radical. Clinical studies using fotemustine have been conducted in malignant glioma, brain metastasis of non-small cell lung cancer, and d... |
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Proton inactivation of melanoma cells enhanced by fotemustine.
Radiat. Prot. Dosimetry 143(2-4) , 503-7, (2011) Response of human HTB140 melanoma cells to proton irradiation in combination with fotemustine (FM) was investigated. Effects of these agents were analysed on cell proliferation and induction of apoptosis. Cells pretreated with 100- or 250-µM of FM were irradi... |
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Chemotherapy in the management of brain metastases: the emerging role of fotemustine for patients with melanoma and NSCLC.
Expert Opin. Drug Saf. 12(5) , 729-40, (2013) An estimated 20 - 40% of cancer patients will develop brain metastases that are the most common intracranial tumors in adults. Patients with cerebral metastases represent a variegate group where selection of the most appropriate treatment depends on many pati... |
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[Immunochemotherapy of metastatic uveal melanoma with interferon alfa-2b, interleukin-2 and fotemustine. Case reports and review of the literature].
Hautarzt 49(10) , 770-3, (1998) In spite of their tumor's origin in the uveal tract, many patients suffering from advanced uveal melanoma are admitted to dermatological oncology units. Most patients with metastases from uveal melanoma receive treatments that were established for stage IV cu... |
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Twice-daily dosing of temozolomide in combination with fotemustine for the treatment of patients with refractory glioblastoma.
Anticancer Res. 32(3) , 1099-101, (2012) Alkylating agents, such as temozolomide (TMZ) and fotemustine (FTM) are widely used in recurrent glioblastoma (GBM) regimes. Several strategies have been proposed to prevent resistance to these agents, by combining or sequencing them. We report the results of... |
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Lecture: fotemustine in brain tumors.
Neurol. Sci. 32 Suppl 2 , S255-7, (2011) Fotemustine (FTMS) is a third-generation nitrosourea, in preclinical studies, FTMS compared favorably with carmustine (BCNU) and lomustine (CCNU) against several human tumor cell lines. In conventional schedule, FTMS is administered at a dose of 100 mg/sqm/we... |