甲麦角林
甲麦角林结构式
|
常用名 | 甲麦角林 | 英文名 | Metergoline |
|---|---|---|---|---|
| CAS号 | 17692-51-2 | 分子量 | 403.51700 | |
| 密度 | 1.25g/cm3 | 沸点 | 612.5ºC at 760mmHg | |
| 分子式 | C25H29N3O2 | 熔点 | 148-150 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 324.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.
Comp. Biochem. Physiol. B Biochem. Mol. Biol. 164(2) , 117-23, (2013) The presence of distinct class of 5-HT receptors in the melanophores of tilapia (Oreochromis mossambicus) is reported. The cellular responses to 5-HT (5-hydroxytryptamine), 5-HT(1), and 5-HT(2), agonists on isolated scale melanophores were observed with regar... |
|
|
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
Elife 4 , (2015) Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that prece... |
|
|
Pharmacological characterisation of the thermogenic effect of bupropion.
Eur. J. Pharmacol. 498(1-3) , 219-25, (2004) The pharmacological mechanism of bupropion's thermogenic effect has been investigated in female Wistar rats by measuring oxygen consumption at thermoneutrality (29 degrees C). Bupropion (30 mg/kg) rapidly increased oxygen consumption (VO2) with a maximum effe... |
|
|
Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.
Eur. J. Pharmacol. 359 , 81, (1998) The effects of the 5-HT1A/1B/1D/5/7 receptor agonist, 5-carboxamidotryptamine (5-CT), on blood glucose, insulin and glucagon levels in rats were investigated. 5-CT above the dosage of 0.05 mg/kg elicited significant hyperglycemic effects and 0.1 mg/kg, induce... |
|
|
Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 302(6) , R740-50, (2012) Cocaine abuse is highly disruptive to circadian physiological and behavioral rhythms. The present study was undertaken to determine whether such effects are manifest through actions on critical photic and nonphotic regulatory pathways in the master circadian ... |
|
|
Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan.
Eur. J. Pharmacol. 227 , 99-102, (1992) We have recently cloned a novel human 5-HT1D receptor subtype termed 5-HT1D beta. CHO K1 cells expressing the human serotonin 5-HT1D beta receptor were assayed to determine the second messenger system of this receptor. Cyclic AMP radioimmunoassays revealed th... |
|
|
Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate.
Am. J. Physiol. 277 , R802-R811, (1999) Systemic treatment with dexfenfluramine (dF), fluoxetine, or serotonin (5-hydroxytryptamine, 5-HT) recently was shown to suppress fat and occasionally protein but not carbohydrate intake in rats when a macronutrient selection paradigm was employed. These repo... |
|
|
The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists.
J. Mol. Graph. Model. 27(1) , 66-81, (2008) We used the MembStruk computational procedure to predict the three-dimensional (3D) structure for the serotonin 5-HT(2C) G-protein-coupled receptor (GPCR). Using this structure, we used the MSCDock computational procedure to predict the 3D structures for boun... |
|
|
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Eur. J. Pharmacol. 535(1-3) , 234-42, (2006) This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to interact with vascular alpha1-adrenoceptors in the pithed rat. These ligands included: methiothepin, m... |
|
|
Inverse agonism at α2A adrenoceptors augments the hypophagic effect of sibutramine in rats.
Obesity (Silver Spring.) 19(10) , 1979-86, (2011) Because the use of monoamine reuptake inhibitors as weight-reducing agents is limited by adverse effects, novel antiobesity drugs are needed. We studied acute effects of the noradrenaline (NA) and serotonin (5-HT) reuptake inhibitor sibutramine (SIB), alone a... |