上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：甲麦角林
纯度：99.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Metergoline
纯度：98.0%
规格：100mg/50mg/1g/1g
联系人：李先生
联系电话：18916172912

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]Metergoline,≥99%
纯度：99.0%
规格：50mg/100mg/100mg/50mg
联系人：夏言
联系电话：18016376636

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17692-51-2生产厂家

17692-51-2价格

17692-51-2

17692-51-2结构式

常用中文名：甲麦角林
常用英文名：Metergoline
CAS号：17692-51-2
分子式：C₂₅H₂₉N₃O₂
分子量：403.51700
相关类别：原料药激素及调节内分泌功能类药垂体激素类药
发布时间：2018-07-05 18:30:31
更新时间：2024-01-08 20:00:30
Metergoline是一种麦角灵化学类的精神药物,常用作各种血清素和多巴胺受体的配体。

化源商城直购

中文名	甲麦角林
英文名	metergoline
中文别名	美塔可宁
英文别名	Metergoline,[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester EINECS 241-686-3 MFCD00153829

描述	Metergoline是一种麦角灵化学类的精神药物,常用作各种血清素和多巴胺受体的配体。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 神经疾病

密度	1.25g/cm3
沸点	612.5ºC at 760mmHg
熔点	148-150 °C(lit.)
分子式	C₂₅H₂₉N₃O₂
分子量	403.51700
闪点	324.2ºC
精确质量	403.22600
PSA	46.50000
LogP	4.39350
蒸汽压	0mmHg at 25°C
储存条件	−20°C
水溶解性	0.1 M HCl: 1.4 mg/mL
分子结构	1、摩尔折射率：117.85 2、摩尔体积（m³/mol）：320.5 3、等张比容（90.2K）：843.4 4、表面张力（dyne/cm）：47.9 5、极化率（10^-24cm³）：46.72
计算化学	1、疏水参数计算参考值（XlogP）：3.8 2、氢键供体数量：1 3、氢键受体数量：3 4、可旋转化学键数量：5 5、互变异构体数量：2 6、拓扑分子极性表面积（TPSA）：46.5 7、重原子数量：30 8、表面电荷：0 9、复杂度：607 10、同位素原子数量：0 11、确定原子立构中心数量：3 12、不确定原子立构中心数量：0 13、确定化学键立构中心数量：0 14、不确定化学键立构中心数量：0 15、共价键单元数量：1
更多	1. 性状：不确定 2. 密度（g/mL,25/4℃）：不确定 3. 相对蒸汽密度（g/mL,空气=1）：不确定 4. 熔点（ºC）：148-150(lit.) 5. 沸点（ºC,常压）：不确定 6. 沸点（ºC, 5.2kPa）：不确定 7. 折射率：不确定 8. 闪点（ºC）：不确定 9. 比旋光度（º）：不确定 10. 自燃点或引燃温度（ºC）：不确定 11. 蒸气压（kPa,25ºC）：不确定 12. 饱和蒸气压（kPa,60ºC）：不确定 13. 燃烧热（KJ/mol）：不确定 14. 临界温度（ºC）：不确定 15. 临界压力（KPa）：不确定 16. 油水（辛醇/水）分配系数的对数值：不确定 17. 爆炸上限（%,V/V）：不确定 18. 爆炸下限（%,V/V）：不确定 19. 溶解性： 0.1 M HCl: 1.4mg/mL

Name:	Metergoline Material Safety Data Sheet
Synonym:
CAS:	17692-51-2

Section 1 - Chemical Product MSDS Name:Metergoline Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
17692-51-2	Metergoline		241-686-3

Hazard Symbols: XN
Risk Phrases: 20/22

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin in harmful amounts.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a tightly closed container. Store in a dry area. Deep freeze (below -20C).

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 17692-51-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 148 deg C(decom)
Autoignition Temperature: 466 deg C ( 870.80 deg F)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 150 deg C
Solubility in water: hardly soluble
Specific Gravity/Density: 0.560
Molecular Formula: C25H29N3O2
Molecular Weight: 403.53

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, direct sunlight..
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 17692-51-2: FA1070000 LD50/LC50:
CAS# 17692-51-2: Oral, mouse: LD50 = 430 mg/kg.
Carcinogenicity:
Metergoline - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
Safety Phrases:
S 7/9 Keep container tightly closed and in a
well-ventilated place.
S 23 Do not inhale gas/fumes/vapour/spray.
WGK (Water Danger/Protection)
CAS# 17692-51-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 17692-51-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 17692-51-2 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

急性毒性：小鼠口经LD50：430 mg/kg；小鼠腹腔LD50：85 mg/kg；小鼠静脉LD50：21200 ug/kg；兔子静脉LD50：20 mg/kg

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FA1070000

CHEMICAL NAME :: Carbamic acid, (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, benzyl ester

CAS REGISTRY NUMBER :: 17692-51-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C25-H29-N3-O2

MOLECULAR WEIGHT :: 403.57

WISWESSER LINE NOTATION :: T C6656 1A P GN LNTT&&J E1MVO1R& G1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4176182

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 ug/kg

SEX/DURATION :: lactating female 5 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum Reproductive - Maternal Effects - other effects

REFERENCE :: OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 51,113,1978

符号	GHS07
信号词	Warning
危害声明	H302-H312-H332
警示性声明	P280
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R20/21/22
安全声明 (欧洲)	S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	FA1070000

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