纳曲酮
纳曲酮结构式
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常用名 | 纳曲酮 | 英文名 | naltrexone |
|---|---|---|---|---|
| CAS号 | 16590-41-3 | 分子量 | 341.40 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 558.1±50.0 °C at 760 mmHg | |
| 分子式 | C20H23NO4 | 熔点 | 168-170ºC | |
| MSDS | N/A | 闪点 | 291.4±30.1 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
J. Pharmacol. Exp. Ther. 350(1) , 69-78, (2014) The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal ... |
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Desensitization of functional µ-opioid receptors increases agonist off-rate.
Mol. Pharmacol. 86(1) , 52-61, (2014) Desensitization of µ-opioid receptors (MORs) develops over 5-15 minutes after the application of some, but not all, opioid agonists and lasts for tens of minutes after agonist removal. The decrease in function is receptor selective (homologous) and could resu... |
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Treatment of alcohol dependence: recent progress and reduction of consumption.
Minerva Med. 105(6) , 447-66, (2014) Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved by both the European Medicines Agency (EMA) and the Food and Drug Administration (FDA): acamprosate, disulfiram, and oral naltrexone. T... |
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Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.
JAMA 311(18) , 1889-900, (2014) Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others... |
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Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response.
Addict. Behav. 38(5) , 2119-27, (2013) The primary analyses of the COMBINE Study revealed significant naltrexone and Combined Behavioral Intervention (CBI) main effects on drinking outcomes but failed to find additional benefits of the combination of treatments. Investigating differences in patter... |
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Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
Am. J. Physiol. Renal Physiol. 305(1) , F52-60, (2013) The role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve (SN) stimulation was studied in anesthetized female rats, using the rat model of isovolumetric bladder contraction. SN stimulation at a fixed frequency of 10 Hz... |
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Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.
Neuron 77(5) , 942-54, (2013) Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (... |
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Therapies for obesity and medication-associated weight gain.
J. Psychosoc. Nurs. Ment. Health Serv. 51(5) , 13-6, (2013) Compared to the general population, individuals with psychiatric illness, especially serious and chronic mood and psychotic disorders, are more likely to be overweight or obese, have higher rates of weight-related medical conditions, and have greater non-suic... |
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Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist.
J. Pharmacol. Exp. Ther. 350(1) , 171-80, (2014) A substituted aryl amide derivative of 6-naltrexamine--17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-trimethylfluoro)benzamido]morphinan-hydrochloride--(compound 5), previously shown to be a potent κ-opioid receptor antagonist, was used to character... |
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[Nalmefene (Selincro) orally].
J. Pharm. Belg. (4) , 51-2, (2014)
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