反-查耳酮

反-查耳酮结构式
反-查耳酮结构式
品牌特惠专场
常用名 反-查耳酮 英文名 (E)-Chalcone
CAS号 614-47-1 分子量 208.255
密度 1.1±0.1 g/cm3 沸点 346.6±25.0 °C at 760 mmHg
分子式 C15H12O 熔点 55-57ºC
MSDS 中文版 美版 闪点 150.1±18.1 °C
符号 GHS07
GHS07
信号词 Warning

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis...

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological ac...

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

J. Med. Chem. 54 , 4147-59, (2011)

Nrf2-mediated activation of antioxidant response element is a central part of molecular mechanisms governing the protective function of phase II detoxification and antioxidant enzymes against carcinogenesis, oxidative stress, and inflammation. Nrf2 is sequest...

Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.

Molecules 20 , 8072-93, (2015)

Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common in the MDR-TB cases, can lead to deleterious life-threatening inflammation ...

Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.

Bioorg. Med. Chem. Lett. 20 , 5818-21, (2010)

Chalcones are involved in the synthesis of flavonoids and are themselves known to exhibit multiple pharmacological properties. However, compared to other structurally similar phytochemicals like garcinol and curcumin, the therapeutic use of chalcones is limit...

A review of anti-infective and anti-inflammatory chalcones.

Eur. J. Med. Chem. 42 , 125-37, (2007)

Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants, and have also been shown to display a diverse array of pharmacological activities. The purpose of this review is to provide an overview of the pharmacologi...

Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives.

J. Agric. Food Chem. 63 , 6749-56, (2015)

Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene derivatives, obtained by chemical synthesis, were studied for antifeedant activity against the peach-potato aphid (Myzus persicae [Su...

The natural compound trans-chalcone induces programmed cell death in Arabidopsis thaliana roots.

Plant Cell Environ. 35(8) , 1500-17, (2012)

Chalcone (1,3-diphenyl-2-propen-1-one) is an aromatic ketone precursor of important molecules in plants such as flavonoids or anthocyanins. Its phytotoxicity has been demonstrated on different plant species, but to date little is known about the mechanisms of...

Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase.

Mol. Biol. Rep. 38(3) , 1617-20, (2011)

Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor was tested for inhibitory activity toward alpha-amylase. Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed...

Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum.

BMC Complement Altern. Med. 13 , 229, (2013)

Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS i...